Automatic detection of microsleep episodes with feature-based machine learning.

Skorucak, Jelena; Hertig-Godeschalk, Anneke; Schreier, David R.; Malafeev, Alexander; Mathis, Johannes; Achermann, Peter (2020). Automatic detection of microsleep episodes with feature-based machine learning. Sleep, 43(1) Oxford University Press 10.1093/sleep/zsz225

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STUDY OBJECTIVES Microsleep episodes (MSEs) are brief episodes of sleep, mostly defined to be shorter than 15 s. In the electroencephalogram (EEG), MSEs are mainly characterized by a slowing in frequency. The identification of early signs of sleepiness and sleep (e.g. MSEs) is of considerable clinical and practical relevance. Under laboratory conditions, the maintenance of wakefulness test (MWT) is often used for assessing vigilance. METHODS We analyzed MWT recordings of 76 patients referred to the Sleep-Wake-Epilepsy-Center. MSEs were scored by experts defined by the occurrence of theta dominance on ≥1 occipital derivation lasting 1-15 s, while the eyes were at least 80% closed. We calculated spectrograms using an autoregressive model of order 16 of 1-s epochs moved in 200-ms steps in order to visualize oscillatory activity and derived seven features per derivation: power in delta, theta, alpha and beta bands, ratio theta/(alpha+beta), quantified eye movements, and median frequency. Three algorithms were used for MSE classification: support vector machine (SVM), random forest (RF), and an artificial neural network (long short-term memory [LSTM] network). Data of 53 patients were used for the training of the classifiers, and 23 for testing. RESULTS MSEs were identified with a high performance (sensitivity, specificity, precision, accuracy, and Cohen's kappa coefficient). Training revealed that delta power and the ratio theta/(alpha+beta) were most relevant features for the RF classifier and eye movements for the LSTM network. CONCLUSIONS The automatic detection of MSEs was successful for our EEG-based definition of MSEs, with good performance of all algorithms applied.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

Graduate School:

Graduate School for Health Sciences (GHS)

UniBE Contributor:

Godeschalk, Anneke Grietje Elizabeth; Schreier, David Raphael and Mathis, Johannes

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1550-9109

Publisher:

Oxford University Press

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

11 Nov 2019 15:09

Last Modified:

15 Jan 2020 01:32

Publisher DOI:

10.1093/sleep/zsz225

PubMed ID:

31559424

Uncontrolled Keywords:

excessive daytime sleepiness machine learning maintenance of wakefulness test microsleep vigilance assessment

BORIS DOI:

10.7892/boris.134859

URI:

https://boris.unibe.ch/id/eprint/134859

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