A cytonaut's guide to protein trafficking in Giardia lamblia.

Faso, Carmen; Hehl, Adrian B. (2019). A cytonaut's guide to protein trafficking in Giardia lamblia. Advances in Parasitology, 106, pp. 105-127. Elsevier 10.1016/bs.apar.2019.08.001

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Over the past years, the subcellular organization of the Excavata member Giardia lamblia (syn. duodenalis, intestinalis) has been investigated in considerable detail. There are several reasons for this endeavour which go beyond this parasite's medical importance and are mostly concerned with its reduced subcellular complexity and debated evolutionary status. One may say that simplification has emerged as a paradigm for the evolution of Giardia's subcellular architecture. However, a complete appreciation of the evolutionary and ecological significance of this phenomenon is far from complete. In this chapter, we present and discuss the most recent data on the main trafficking pathways in G. lamblia which include endo- and exo-cytosis, organellar import and function. We provide perspectives on open questions concerning organelle replication and inheritance and include a technical outlook on methods and approaches to genetic manipulations in G. lamblia. A better understanding of G. lamblia subcellular organization at the morphological and molecular level complements any effort aimed at elucidating this parasitic species' evolutionary status and could provide us with the basis for novel strategies to interfere with parasite transmission and/or pathogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology

UniBE Contributor:

Faso, Carmen and Hehl, Adrian Benedikt

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

2163-6079

Publisher:

Elsevier

Funders:

[4] Swiss National Science Foundation

Language:

English

Submitter:

Carmen Faso

Date Deposited:

14 Nov 2019 15:59

Last Modified:

14 Nov 2019 15:59

Publisher DOI:

10.1016/bs.apar.2019.08.001

PubMed ID:

31630756

URI:

https://boris.unibe.ch/id/eprint/134877

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