Stem cell treatment and cerebral palsy: Systemic review and meta-analysis.

Eggenberger, Simone; Boucard, Céline; Schoeberlein, Andreina; Guzman, Raphael; Limacher, Andreas; Surbek, Daniel; Mueller, Martin (2019). Stem cell treatment and cerebral palsy: Systemic review and meta-analysis. World journal of stem cells, 11(10), pp. 891-903. Baishideng Publishing Group 10.4252/wjsc.v11.i10.891

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BACKGROUND Perinatal complications may result in life-long morbidities, among which cerebral palsy (CP) is the most severe motor disability. Once developed, CP is a non-progressive disease with a prevalence of 1-2 per 1000 live births in developed countries. It demands an extensive and multidisciplinary care. Therefore, it is a challenge for our health system and a burden for patients and their families. Recently, stem cell therapy emerged as a promising treatment option and raised hope in patients and their families. AIM The aim is to evaluate the efficacy and safety of stem cell treatment in children with CP using a systematic review and meta-analysis. METHODS We performed a systematic literature search on PubMed and EMBASE to find randomized controlled clinical trials (RCT) investigating the effect of stem cell transplantation in children with CP. After the review, we performed a random-effects meta-analysis focusing on the change in gross motor function, which was quantified using the gross motor function measure. We calculated the pooled standardized mean differences of the 6- and/or 12-mo-outcome by the method of Cohen. We quantified the heterogeneity using the I-squared measure. RESULTS We identified a total of 8 RCT for a qualitative review. From the initially selected trials, 5 met the criteria and were included in the meta-analysis. Patients' population ranged from 0.5 up to 35 years (n = 282). We detected a significant improvement in the gross motor function with a pooled standard mean difference of 0.95 (95% confidence interval: 0.13-1.76) favoring the stem cell group and a high heterogeneity (I2 = 90.1%). Serious adverse events were rare and equally distributed among both intervention and control groups. CONCLUSION Stem cell therapy for CP compared with symptomatic standard care only, shows a significant positive effect on the gross motor function, although the magnitude of the improvement is limited. Short-term safety is present and further high-quality RCTs are needed.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Pränatale Medizin
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Schoeberlein, Andreina; Limacher, Andreas; Surbek, Daniel and Müller, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1948-0210

Publisher:

Baishideng Publishing Group

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

14 Nov 2019 11:02

Last Modified:

14 Nov 2019 11:02

Publisher DOI:

10.4252/wjsc.v11.i10.891

PubMed ID:

31692977

Uncontrolled Keywords:

Cerebral palsy Gross motor function Mesenchymal stem/stromal cells Meta-analysis Perinatal brain injury Stem cells Umbilical cord blood

BORIS DOI:

10.7892/boris.134895

URI:

https://boris.unibe.ch/id/eprint/134895

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