A Comparative Analysis of Individual RAS Mutations in Cancer Biology.

Muñoz-Maldonado, Carmen; Zimmer, Yitzhak; Medova, Michaela (2019). A Comparative Analysis of Individual RAS Mutations in Cancer Biology. Frontiers in oncology, 9, p. 1088. Frontiers Research Foundation 10.3389/fonc.2019.01088

[img]
Preview
Text
fonc-09-01088.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (1MB) | Preview

In human cells, three closely related RAS genes, termed HRAS, KRAS, and NRAS, encode four highly homologous proteins. RAS proteins are small GTPases involved in a broad spectrum of key molecular and cellular activities, including proliferation and survival among others. Gain-of-function missense mutations, mostly located at codons 12, 13, and 61, constitutively activate RAS proteins and can be detected in various types of human cancers. KRAS is the most frequently mutated, followed by NRAS and HRAS. However, each isoform exhibits distinctive mutation frequency at each codon, supporting the hypothesis that different RAS mutants may lead to distinct biologic manifestations. This review is focused on the differences in signaling and phenotype, as well as on transcriptomics, proteomics, and metabolomics profiles related to individual RAS-mutated variants. Additionally, association of these mutants with particular targeted outcomes and rare mutations at additional RAS codons are discussed.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Radio-Onkologie

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Muñoz Maldonado, Carmen; Zimmer, Yitzhak and Medova, Michaela

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2234-943X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

26 Nov 2019 14:49

Last Modified:

08 Dec 2019 02:45

Publisher DOI:

10.3389/fonc.2019.01088

PubMed ID:

31681616

Uncontrolled Keywords:

GTP/GDP binding RAS mutations RAS profile RAS signaling RAS-mutated cancers RAS-related omics rare codons treatment responses

BORIS DOI:

10.7892/boris.134935

URI:

https://boris.unibe.ch/id/eprint/134935

Actions (login required)

Edit item Edit item
Provide Feedback