Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop.

Nikolaidis, Christos; Ming, Chang; Pedrazzani, Carla; van der Horst, Tina; Kaiser-Grolimund, Andrea; Ademi, Zanfina; Bührer-Landolt, Rosmarie; Bürki, Nicole; Caiata-Zufferey, Maria; Champion, Victoria; Chappuis, Pierre O; Kohler, Carmen; Erlanger, Tobias E; Graffeo, Rossella; Hampel, Heather; Heinimann, Karl; Heinzelmann-Schwarz, Viola; Kurzeder, Christian; Monnerat, Christian; Northouse, Laurel L; ... (2018). Challenges and Opportunities for Cancer Predisposition Cascade Screening for Hereditary Breast and Ovarian Cancer and Lynch Syndrome in Switzerland: Findings from an International Workshop. Public health genomics, 21(3-4), pp. 121-132. Karger 10.1159/000496495

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BACKGROUND

An international workshop on cancer predisposition cascade genetic screening for hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) took place in Switzerland, with leading researchers and clinicians in cascade screening and hereditary cancer from different disciplines. The purpose of the workshop was to enhance the implementation of cascade genetic screening in Switzerland. Participants discussed the challenges and opportunities associated with cascade screening for HBOC and LS in Switzerland (CASCADE study); family implications and the need for family-based interventions; the need to evaluate the cost-effectiveness of cascade genetic screening; and interprofessional collaboration needed to lead this initiative.

METHODS

The workshop aims were achieved through exchange of data and experiences from successful cascade screening programs in the Netherlands, Australia, and the state of Ohio, USA; Swiss-based studies and scientific experience that support cancer cascade screening in Switzerland; programs of research in psychosocial oncology and family-based studies; data from previous cost-effectiveness analyses of cascade genetic screening in the Netherlands and in Australia; and organizational experience from a large interprofessional collaborative. Scientific presentations were recorded and discussions were synthesized to present the workshop findings.

RESULTS

The key elements of successful implementation of cascade genetic screening are a supportive network of stakeholders and connection to complementary initiatives; sample size and recruitment of relatives; centralized organization of services; data-based cost-effectiveness analyses; transparent organization of the initiative; and continuous funding.

CONCLUSIONS

This paper describes the processes and key findings of an international workshop on cancer predisposition cascade screening, which will guide the CASCADE study in Switzerland.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Rabaglio, Manuela

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1662-8063

Publisher:

Karger

Language:

English

Submitter:

Rebeka Gerber

Date Deposited:

15 Nov 2019 16:22

Last Modified:

15 Nov 2019 16:22

Publisher DOI:

10.1159/000496495

PubMed ID:

30695780

Uncontrolled Keywords:

Cascade genetic screening Hereditary breast and ovarian cancer Implementation science Lynch syndrome Public health genetics

URI:

https://boris.unibe.ch/id/eprint/134973

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