Mycoplasma pneumoniae associated opsoclonus-myoclonus syndrome in three cases

Huber, Benedikt Maria; Strozzi, Susi; Steinlin, Maja; Aebi, Christoph; Fluri, Simon (2010). Mycoplasma pneumoniae associated opsoclonus-myoclonus syndrome in three cases. European journal of pediatrics, 169(4), pp. 441-5. Berlin: Springer-Verlag 10.1007/s00431-009-1048-3

[img]
Preview
Text
431_2009_Article_1048.pdf - Published Version
Available under License Publisher holds Copyright.

Download (112kB) | Preview

Opsoclonus-myoclonus syndrome (OMS) is a rare acquired movement disorder occurring in all age groups, predominantly in infants. Although the exact pathogenesis is still undefined, there is strong evidence for a paraneoplastic or parainfectious immune process resulting in central nervous system dysfunction. Mycoplasma pneumoniae has been implicated in a number of immune-mediated neurologic diseases [28]. However, the association of M. pneumoniae and opsoclonus-myoclonus-ataxia syndrome is not well established so far. We present three cases with opsoclonus-myoclonus-ataxia syndrome in adolescents following an infection with M. pneumoniae. Monophasic disease course and full recovery correspond to the favorable prognosis known from parainfectious cases in young adults. This should affect therapeutic consideration. OMS should be added to the spectrum of M. pneumoniae-associated neurologic complications. Nevertheless, neuroblastoma has to be ruled out in all cases of OMS.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine

UniBE Contributor:

Huber, Benedikt Maria; Strozzi, Susi; Steinlin, Maja; Aebi, Christoph and Fluri, Simon

ISSN:

0340-6199

Publisher:

Springer-Verlag

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:07

Last Modified:

22 Oct 2019 20:47

Publisher DOI:

10.1007/s00431-009-1048-3

PubMed ID:

19774394

Web of Science ID:

000274456200009

BORIS DOI:

10.7892/boris.135

URI:

https://boris.unibe.ch/id/eprint/135 (FactScience: 196472)

Actions (login required)

Edit item Edit item
Provide Feedback