Immunogenicity and Immunodominance in Antibody Responses.

Vogel, Monique; Bachmann, Martin F. (2020). Immunogenicity and Immunodominance in Antibody Responses. Current topics in microbiology and immunology, 428, pp. 89-102. Springer 10.1007/82_2019_160

[img] Text
2019_Chapter_.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (291kB) | Request a copy

A large number of vaccines exist that control many of the most important infectious diseases. Despite these successes, there remain many pathogens without effective prophylactic vaccines. Notwithstanding strong difference in the biology of these infectious agents, there exist common problems in vaccine design. Many infectious agents have highly variable surface antigens and/or unusually high antibody levels are required for protection. Such high variability may be addressed by using conserved epitopes and these are, however, usually difficult to display with the right conformation in an immunogenic fashion. Exceptionally high antibody titers may be achieved using life vectors or virus-like display of the epitopes. Hence, an important goal in modern vaccinology is to induce high antibody responses against fragile antigens.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Rheumatology, Clinical Immunology and Allergology

UniBE Contributor:

Vogel, Monique and Bachmann, Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0070-217X

Publisher:

Springer

Language:

English

Submitter:

Burkhard Möller

Date Deposited:

15 Nov 2019 15:41

Last Modified:

04 Sep 2020 01:30

Publisher DOI:

10.1007/82_2019_160

PubMed ID:

30919087

BORIS DOI:

10.7892/boris.135059

URI:

https://boris.unibe.ch/id/eprint/135059

Actions (login required)

Edit item Edit item
Provide Feedback