Leishmaniasis manifesting as osteomyelitis and monoarthritis in a dog and outcome following treatment with mitefosine and allopurinol.

König, Maya Laura; Howard, Judith; Schmidhalter, Marta; Hentrich, Brigitte; Hettlich, Bianca (2019). Leishmaniasis manifesting as osteomyelitis and monoarthritis in a dog and outcome following treatment with mitefosine and allopurinol. Veterinary Record Case Reports, 7(1), e000793. British Veterinary Association 10.1136/vetreccr-2018-000793

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A nine-year-old male, neutered, mixed-breed dog was presented with chronic left pelvic limb lameness, moderate muscular atrophy and pain on palpation of the lateral femoral condyle. No other clinical abnormalities were found except for two subcutaneous tarsal nodules. Radiographs and CT revealed severe stifle monoarthropathy and distal femoral osteolysis without periosteal proliferation, mild popliteal lymphadenopathy and several small splenic nodules. Leishmaniosis was diagnosed on cytology of the lymph nodes and spleen, serology and PCR of the synovial membrane, and bone biopsies. Complete clinical remission was achieved with oral miltefosine and allopurinol. The areas of distal femur bone loss remained radiographically and on CT. Monarthritis and osteomyelitis without systemic clinical signs or clinicopathological alterations have rarely been reported with canine leishmaniosis. Leishmaniosis should be considered even if radiographic signs are atypical. Treatment with miltefosine and allopurinol was successful in achieving clinical remission. Previous areas of bone loss remained quiescent without bone infilling.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

05 Veterinary Medicine > Department of Infectious Diseases and Pathobiology (DIP) > Institute of Parasitology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > Small Animal Clinic > Small Animal Clinic, Surgery
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Central Clinical Laboratory

UniBE Contributor:

König, Maya Laura; Howard, Judith; Schmidhalter, Marta; Hentrich, Brigitte and Hettlich, Bianca Felicitas

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2052-6121

Publisher:

British Veterinary Association

Language:

English

Submitter:

Bianca Felicitas Hettlich

Date Deposited:

19 Nov 2019 15:45

Last Modified:

24 Nov 2019 02:45

Publisher DOI:

10.1136/vetreccr-2018-000793

BORIS DOI:

10.7892/boris.135075

URI:

https://boris.unibe.ch/id/eprint/135075

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