Heart Transplantation With Donation After Circulatory Death

Niederberger, Petra; Farine, Emilie; Raillard, Mathieu Clément; Dornbierer, Monika; Freed, Darren H.; Large, Stephen R.; Chew, Hong C.; MacDonald, Peter S.; Messer, Simon J.; White, Christopher W.; Carrel, Thierry; Tevaearai Stahel, Hendrik T.; Longnus, Sarah L. (2019). Heart Transplantation With Donation After Circulatory Death. Circulation - heart failure, 12(4), pp. 1-14. Lippincott Williams & Wilkins 10.1161/CIRCHEARTFAILURE.118.005517

[img] Text
Heart transplantation with donation after circulatory death.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (491kB) | Request a copy

Heart transplantation remains the preferred option for improving quality of life and survival for patients suffering from end-stage heart failure. Unfortunately, insufficient supply of cardiac grafts has become an obstacle. Increasing organ availability with donation after circulatory death (DCD) may be a promising option to overcome the organ shortage. Unlike conventional donation after brain death, DCD organs undergo a period of warm, global ischemia between circulatory arrest and graft procurement, which raises concerns for graft quality. Nonetheless, the potential of DCD heart transplantation is being reconsidered, after reports of more than 70 cases in Australia and the United Kingdom over the past 3 years. Ensuring optimal patient outcomes and generalized adoption of DCD in heart transplantation, however, requires further development of clinical protocols, which in turn require a better understanding of cardiac ischemia-reperfusion injury and the various possibilities to limit its adverse effects. Thus, we aim to provide an overview of the knowledge obtained with preclinical studies in animal models of DCD heart transplantation, to facilitate and promote the most effective and efficient advancement in preclinical research. A literature search of the PubMed database was performed to identify all relevant preclinical studies in DCD heart transplantation. Specific aspects relevant for DCD heart transplantation were analyzed, including animal models, graft procurement and storage conditions, cardioprotective approaches, and graft evaluation strategies. Several potential therapeutic strategies for optimizing graft quality are identified, and recommendations for further preclinical research are provided.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiovascular Surgery
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Herz- und Gefässchirurgie

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology

UniBE Contributor:

Niederberger, Petra; Raillard, Mathieu Clément; Carrel, Thierry and Henning Longnus, Sarah


600 Technology > 610 Medicine & health




Lippincott Williams & Wilkins




Claudia Stalder

Date Deposited:

27 Nov 2019 15:52

Last Modified:

27 Nov 2019 15:52

Publisher DOI:


PubMed ID:






Actions (login required)

Edit item Edit item
Provide Feedback