A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research.

Muka, Taulant; Glisic, Marija; Milic, Jelena; Verhoog, Sanne; Bohlius, Julia; Bramer, Wichor; Chowdhury, Rajiv; Franco, Oscar H (2020). A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research. European journal of epidemiology, 35(1), pp. 49-60. Springer 10.1007/s10654-019-00576-5

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To inform evidence-based practice in health care, guidelines and policies require accurate identification, collation, and integration of all available evidence in a comprehensive, meaningful, and time-efficient manner. Approaches to evidence synthesis such as carefully conducted systematic reviews and meta-analyses are essential tools to summarize specific topics. Unfortunately, not all systematic reviews are truly systematic, and their quality can vary substantially. Since well-conducted evidence synthesis typically involves a complex set of steps, we believe formulating a cohesive, step-by-step guide on how to conduct a systemic review and meta-analysis is essential. While most of the guidelines on systematic reviews focus on how to report or appraise systematic reviews, they lack guidance on how to synthesize evidence efficiently. To facilitate the design and development of evidence syntheses, we provide a clear and concise, 24-step guide on how to perform a systematic review and meta-analysis of observational studies and clinical trials. We describe each step, illustrate it with concrete examples, and provide relevant references for further guidance. The 24-step guide (1) simplifies the methodology of conducting a systematic review, (2) provides healthcare professionals and researchers with methodologically sound tools for conducting systematic reviews and meta-analyses, and (3) it can enhance the quality of existing evidence synthesis efforts. This guide will help its readers to better understand the complexity of the process, appraise the quality of published systematic reviews, and better comprehend (and use) evidence from medical literature.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

UniBE Contributor:

Muka, Taulant; Glisic, Marija; Verhoog, Sanne; Bohlius, Julia and Franco Duran, Oscar Horacio

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services

ISSN:

0393-2990

Publisher:

Springer

Language:

English

Submitter:

Beatrice Minder Wyssmann

Date Deposited:

15 Nov 2019 16:39

Last Modified:

14 Nov 2020 02:30

Publisher DOI:

10.1007/s10654-019-00576-5

PubMed ID:

31720912

Additional Information:

Taulant Muka and Marija Glisic have contributed equally to this
work.
Wichor Bramer and Rajiv Chowdhury have contributed equally to this work.

Uncontrolled Keywords:

24 Steps Evidence synthesis Guideline Meta-analysis Systematic review

BORIS DOI:

10.7892/boris.135129

URI:

https://boris.unibe.ch/id/eprint/135129

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