A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque induced gingivitis.

Nardi, Gianna Maria; Grassi, Roberta; Campus, Guglielmo; Pareti, Maria Letizia; Di Stasio, Dario; Della Vella, Fedora (2019). A chlorhexidine-containing brush-on gel as adjuvant treatment for plaque induced gingivitis. (In Press). Current topics in medicinal chemistry Bentham Science Publishers 10.2174/1568026619666191114120218

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The aim of the present study was to evaluate the effects of a chlorhexidine brush-on gel application on plaque-induced gingivitis.
Consecutive patients diagnosed with gingivitis were enrolled. For each patient, full mouth plaque score and gingival index were recorded during the first visit (t0) and after 1 week (t1), 2 weeks (t2) and 3 weeks (t3). Patients were randomly divided into a study group, who received instruction to brush their teeth daily with a chlorhexidine-based gel, and a control group, treated with a placebo gel. The chi-square test was used to compare the groups baseline, while the t-Student and the Mann-Whitney tests were performed to evaluate the significance of groups indexes improvement, individually and compared.
Thirty participants were enrolled: 15 referred to the study group and 15 to the control group. The study group showed a reduction of plaque score and gingival index of 87% and 84% respectively (p<0.05), while the control group plaque score and gingival index decreased of 75% and 80% (p<0.05). The study group plaque score reduction resulted to be statistically more significant than the control group one.
The topical application of a chlorhexidine-based brush-on gel can be a useful adjunctive domiciliary treatment for gingivitis therapy, combined with the mechanical debridement, that still remains the gold standard.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Preventive, Restorative and Pediatric Dentistry

UniBE Contributor:

Campus, Guglielmo Giuseppe


600 Technology > 610 Medicine & health




Bentham Science Publishers




Guglielmo Giuseppe Campus

Date Deposited:

04 Dec 2019 09:01

Last Modified:

05 Dec 2019 01:33

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Chlorhexidine; Gingivitis; Oral Hygiene; Topical Gel



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