Leiherer, Andreas; Muendlein, Axel; Saely, Christoph H; Fraunberger, Peter; Drexel, Heinz (2019). Serotonin is elevated in risk-genotype carriers of TCF7L2 - rs7903146. Scientific reports, 9(1), p. 12863. Springer Nature 10.1038/s41598-019-49347-y
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Leiherer_Serotonin is elevated in risk-genotype carriers_ScientificReports.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (1MB) | Preview |
The transcription factor 7-like 2 (TCF7L2) polymorphism rs7903146 is known to be tightly associated with an elevated risk for type 2 diabetes, whereas the molecular mechanisms remain elusive. We evaluated the metabolic profile of a total of 394 patients' serum samples with respect to their rs7903146 genotype using targeted metabolomics in a discovery (n = 154) and a validation (n = 240) study. We have identified serotonin as the top metabolite being increased in carriers of the risk allele. Serotonin was significantly associated with the rs7903146 genotype after full adjustment including type 2 diabetes and further top ranked metabolites. Given the role of peripheral serotonin in metabolic homeostasis and type 2 diabetes, this finding provides a first hint that the well-known impact of the TCF7L2 polymorphism on type 2 diabetes risk may involve a serotonin-dependent pathway.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Angiology |
UniBE Contributor: |
Drexel, Heinz |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Isabel Lorenz |
Date Deposited: |
20 Nov 2019 10:30 |
Last Modified: |
05 Dec 2022 15:32 |
Publisher DOI: |
10.1038/s41598-019-49347-y |
PubMed ID: |
31492908 |
BORIS DOI: |
10.7892/boris.135233 |
URI: |
https://boris.unibe.ch/id/eprint/135233 |
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