The Rapid TEG α-Angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients

Jeger, Victor; Willi, Sandra; Liu, Tun; Yeh, Daniel D.; De Moya, Marc; Zimmermann, Heinz; Exadaktylos, Aristomenis K. (2012). The Rapid TEG α-Angle may be a sensitive predictor of transfusion in moderately injured blunt trauma patients. Scientific world journal, 2012, p. 821794. New York, N.Y.: Hindawi Publishing Corporation 10.1100/2012/821794

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Background. To guide the administration of blood products, coagulation screening of trauma patients should be fast and accurate. The purpose of this study was to identify the correlation between CCT and TEG in trauma, to determine which CCT or TEG parameter is most sensitive in predicting transfusion in trauma, and to define TEG cut-off points for trauma care. Methods. A six-month, prospective observational study of 76 adult patients with suspected multiple injuries was conducted at a Level 1 trauma centre of a university hospital. Physicians blinded to TEG results made the decision to transfuse based on clinical evaluation. Results. The study results showed that conventional coagulation tests correlate moderately with Rapid TEG parameters (R: 0.44–0.61). Kaolin and Rapid TEG were more sensitive than CCTs, and the Rapid TEG α-Angle was identified as the single parameter with the greatest sensitivity (84%) and validity (77%) at a cut-off of 74.7 degrees. When the Rapid TEG α-Angle was combined with heart rate >75 bpm, or haematocrit < 41%, sensitivity (84%, 88%) and specificity (75%, 73%) were improved. Conclusion. Cutoff points for transfusion can be determined with the Rapid TEG α-Angle and can provide better sensitivity than CCTs, but a larger study population is needed to reproduce this finding.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > University Emergency Center

UniBE Contributor:

Jeger, Victor; Zimmermann, Heinz and Exadaktylos, Aristomenis Konstantinos

ISSN:

1537-744X

Publisher:

Hindawi Publishing Corporation

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

12 Dec 2014 21:26

Publisher DOI:

10.1100/2012/821794

PubMed ID:

22547997

Web of Science ID:

000303008100001

BORIS DOI:

10.7892/boris.13526

URI:

https://boris.unibe.ch/id/eprint/13526 (FactScience: 220078)

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