Verspoor, Eline; Voortman, Trudy; van Rooij, Frank J A; Rivadeneira, Fernando; Franco, Oscar H; Kiefte-de Jong, Jessica C; Schoufour, Josje D (2020). Macronutrient intake and frailty: the Rotterdam Study. European Journal of Nutrition, 59(7), pp. 2919-2928. Springer-Verlag 10.1007/s00394-019-02131-0
|
Text
Verspoor_EurJNutr_2020.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (784kB) | Preview |
PURPOSE
To investigate the longitudinal association between the macronutrient composition of the diet and frailty.
METHODS
Data were obtained from 5205 Dutch middle-aged and older adults participating in the Rotterdam Study. Frailty was measured using a frailty index based on the accumulation of 38 health-related deficits, score between 0 and 100, and a higher score indicating more frailty. Frailty was assessed at baseline and 11 years later (range of 23 years). Macronutrient intake was assessed using food-frequency questionnaires. The association between macronutrients and frailty over time was evaluated using multivariable linear regression, adjusted for the frailty index at baseline, energy intake, and other relevant confounders. All analyses were performed in strata of BMI.
RESULTS
Median frailty index score was 13.8 points (IQR 9.6; 19.1) at baseline and increased by a median of 2.3 points (IQR - 2.0; 7.6) after 11 years. Overall, we found no significant associations between intake of carbohydrates or fat and frailty over time. We did observe a significant positive association between an iso-energetic intake of 10 g protein and frailty over time (β 0.31 (95% CI 0.06; 0.55)) which was mainly driven by animal protein (β 0.31 (95% CI 0.07; 0.56)). It did not depend on whether it was substituted fat or carbohydrates.
CONCLUSIONS
Our findings suggest that a reduction in the intake of animal protein may improve the overall health status over time in a relatively healthy population. More research is needed on the optimal macronutrient composition of the diet and frailty in more vulnerable populations.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Franco Duran, Oscar Horacio |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1436-6207 |
Publisher: |
Springer-Verlag |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
22 Nov 2019 11:18 |
Last Modified: |
05 Dec 2022 15:32 |
Publisher DOI: |
10.1007/s00394-019-02131-0 |
PubMed ID: |
31728680 |
Uncontrolled Keywords: |
Frailty Frailty index Macronutrient intake Older adults |
BORIS DOI: |
10.7892/boris.135274 |
URI: |
https://boris.unibe.ch/id/eprint/135274 |
Actions (login required)
 |
Edit item |