Dynamic modulation of theta-gamma coupling during REM sleep.

Bandarabadi, Mojtaba; Boyce, Richard; Gutierrez Herrera, Carolina; Bassetti, Claudio; Williams, Sylvain; Schindler, Kaspar; Adamantidis, Antoine (2019). Dynamic modulation of theta-gamma coupling during REM sleep. Sleep, 42(12) Oxford University Press 10.1093/sleep/zsz182

Text Bandarabadi, 2019, Dynamic modulation of theta-gamma coupling during REM sleep.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (3MB) | Request a copy

Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation, however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta-gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta-gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta-gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e., cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.

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