Dynamic modulation of theta-gamma coupling during REM sleep.

Bandarabadi, Mojtaba; Boyce, Richard; Gutierrez Herrera, Carolina; Bassetti, Claudio; Williams, Sylvain; Schindler, Kaspar; Adamantidis, Antoine (2019). Dynamic modulation of theta-gamma coupling during REM sleep. Sleep, 42(12) Oxford University Press 10.1093/sleep/zsz182

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Theta phase modulates gamma amplitude in hippocampal networks during spatial navigation and rapid eye movement (REM) sleep. This cross-frequency coupling has been linked to working memory and spatial memory consolidation, however, its spatial and temporal dynamics remains unclear. Here, we first investigate the dynamics of theta-gamma interactions using multiple frequency and temporal scales in simultaneous recordings from hippocampal CA3, CA1, subiculum, and parietal cortex in freely moving mice. We found that theta phase dynamically modulates distinct gamma bands during REM sleep. Interestingly, we further show that theta-gamma coupling switches between recorded brain structures during REM sleep and progressively increases over a single REM sleep episode. Finally, we show that optogenetic silencing of septohippocampal GABAergic projections significantly impedes both theta-gamma coupling and theta phase coherence. Collectively, our study shows that phase-space (i.e., cross-frequency coupling) coding of information during REM sleep is orchestrated across time and space consistent with region-specific processing of information during REM sleep including learning and memory.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DCR Unit Sahli Building > Forschungsgruppe Neurologie
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Bandarabadi, Mojtaba; Gutierrez Herrera, Carolina; Bassetti, Claudio; Schindler, Kaspar Anton and Adamantidis, Antoine Roger

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1550-9109

Publisher:

Oxford University Press

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

26 Nov 2019 17:02

Last Modified:

27 Dec 2019 01:32

Publisher DOI:

10.1093/sleep/zsz182

PubMed ID:

31410477

Uncontrolled Keywords:

REM sleep active wake hippocampus optogenetics theta-gamma coupling

BORIS DOI:

10.7892/boris.135399

URI:

https://boris.unibe.ch/id/eprint/135399

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