Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape

Sakhnevych, Svetlana S.; Yasinska, Inna M.; Fasler-Kan, Elizaveta; Sumbayev, Vadim V. (2019). Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape. Frontiers in Pharmacology, 10 Frontiers 10.3389/fphar.2019.00342

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The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Research Group Pediatric Surgery
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery

UniBE Contributor:

Fasler-Kan, Elizaveta

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1663-9812

Publisher:

Frontiers

Language:

English

Submitter:

Christoph Steffen

Date Deposited:

05 Dec 2019 15:46

Last Modified:

05 Dec 2022 15:32

Publisher DOI:

10.3389/fphar.2019.00342

BORIS DOI:

10.7892/boris.135429

URI:

https://boris.unibe.ch/id/eprint/135429

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