Sakhnevych, Svetlana S.; Yasinska, Inna M.; Fasler-Kan, Elizaveta; Sumbayev, Vadim V. (2019). Mitochondrial Defunctionalization Supresses Tim-3-Galectin-9 Secretory Pathway in Human Colorectal Cancer Cells and Thus Can Possibly Affect Tumor Immune Escape. Frontiers in Pharmacology, 10 Frontiers 10.3389/fphar.2019.00342
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The Tim-3-galectin-9 secretory pathway is known to protect various types of cancer cells against host immune surveillance. We found that pharmacologically induced mitochondrial dysfunction leads to a reduced galectin-9 expression/exocytosis in human colorectal cancer cells and re-distribution of this protein (the effect described for various cellular proteins) into mitochondria.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Research Group Pediatric Surgery 04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Surgery |
UniBE Contributor: |
Fasler-Kan, Elizaveta |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1663-9812 |
Publisher: |
Frontiers |
Language: |
English |
Submitter: |
Christoph Steffen |
Date Deposited: |
05 Dec 2019 15:46 |
Last Modified: |
05 Dec 2022 15:32 |
Publisher DOI: |
10.3389/fphar.2019.00342 |
BORIS DOI: |
10.7892/boris.135429 |
URI: |
https://boris.unibe.ch/id/eprint/135429 |
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