Efficacy of Amniotic Membrane Transplantation for the Treatment of Corneal Ulcers.

Schuerch, Kaspar; Baeriswyl, Andrea; Frueh, Beatrice E.; Tappeiner, Christoph (2020). Efficacy of Amniotic Membrane Transplantation for the Treatment of Corneal Ulcers. Cornea, 39(4), pp. 479-483. Wolters Kluwer Health 10.1097/ICO.0000000000002179

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PURPOSE

To evaluate the outcome of amniotic membrane transplantation (AMTX) as a treatment for corneal ulcers.

METHODS

Patients treated with AMTX for refractory corneal ulcers between 2012 and 2017 were evaluated in a retrospective analysis. Primary outcome measure was complete reepithelialization.

RESULTS

A total of 149 patients were included (mean age 68 ± 18 years). The mean duration between ulcer onset and AMTX was 42 ± 46 days. The longest time between ulcer diagnosis and AMTX was found in bacterial ulcers and the shortest time to AMTX in eyes with trauma/chemical burns (mean 65 ± 15 days and 14 ± 4 days, respectively). In 70% of the patients, a single AMTX procedure was sufficient to achieve epithelial closure (21% <1 month, 40% within 1 -3 months, and 9% within 3-6 months). Treatment failure was observed in 30% of all patients, and most of them underwent further interventions. Highest closure rates were found in bacterial ulcers, herpetic ulcers, and neurotrophic ulcers (80%, 85%, and 93%, respectively), whereas the lowest reepithelialization rates were found in ulcers after corneal surgery and ulcers associated with rheumatic disease (52% and 57%, respectively).

CONCLUSIONS

AMTX is a valuable treatment option to achieve corneal epithelial wound healing in cases refractory to conventional treatment. Success rates differ depending on the etiology of ulcer.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Schürch, Kaspar Werner; Früh Epstein, Beatrice and Tappeiner, Christoph

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0277-3740

Publisher:

Wolters Kluwer Health

Language:

English

Submitter:

Christoph Tappeiner

Date Deposited:

04 Dec 2019 10:30

Last Modified:

17 Oct 2020 02:30

Publisher DOI:

10.1097/ICO.0000000000002179

PubMed ID:

31634228

BORIS DOI:

10.7892/boris.135563

URI:

https://boris.unibe.ch/id/eprint/135563

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