Effect of CIMicifuga racemosa on metaBOLIC parameters in women with menopausal symptoms: a retrospective observational study (CIMBOLIC).

Friederichsen, Lena; Nebel, Sabine; Zahner, Catherine; Bütikofer, Lukas; Stute, Petra (2020). Effect of CIMicifuga racemosa on metaBOLIC parameters in women with menopausal symptoms: a retrospective observational study (CIMBOLIC). Archives of gynecology and obstetrics, 301(2), pp. 517-523. Springer-Verlag 10.1007/s00404-019-05366-8

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PURPOSE

To compare the influence of Cimicifuga racemosa extract (CR, Ze 450) and menopausal hormone therapy (MHT) on metabolic parameters and body weight in symptomatic menopausal women.

METHODS

In this monocentric retrospective cohort study, women over 40 years old with a first consultation between 2009 and 2016 were screened. Included in the final analysis were women treated with either MHT or CR and having at least one follow-up consultation. Metabolic serum parameters (lipids, glucose, insulin, and HOMA-IR), body weight, and menopausal symptoms [Menopause Rating Scale (MRS)-II] were the main outcome measures. Statistical analysis by uni- and multi-variable linear mixed-effects regression models assuming a linear effect of time.

RESULTS

174 women were included in the final analysis (CR n = 32, MHT n = 142). There was no difference between the groups regarding baseline characteristics (age, BMI, serum metabolic parameters, hormones, and blood pressure) and total MRS-II score, while reproductive stage differed significantly with more postmenopausal women treated with CR (83%) than MHT (55%) (p = 0.038). Median follow-up time was 12 months. In both groups, metabolic serum parameters and body weight did not change over the follow-up period, while total and MRS-II subscores improved.

CONCLUSION

Menopausal symptoms improved significantly in both groups (MHT and CR), while serum metabolic parameters and body weight did not change in MHT- or CR-treated women.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Endokrinologie der Brust
04 Faculty of Medicine > Pre-clinic Human Medicine > CTU Bern

UniBE Contributor:

Bütikofer, Lukas and Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0932-0067

Publisher:

Springer-Verlag

Language:

English

Submitter:

Andrea Flükiger-Flückiger

Date Deposited:

04 Dec 2019 08:22

Last Modified:

11 Aug 2020 18:06

Publisher DOI:

10.1007/s00404-019-05366-8

PubMed ID:

31734757

Uncontrolled Keywords:

Black cohosh Body weight Cimicifuga racemosa HOMA index Menopausal hormone therapy Menopause

BORIS DOI:

10.7892/boris.135628

URI:

https://boris.unibe.ch/id/eprint/135628

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