Drews, Elisa; Fertuck, Eric A.; Koenig, Julian; Kaess, Michael; Arntz, Arnoud (2019). Hypothalamic-pituitary-adrenal axis functioning in borderline personality disorder: A meta-analysis. Neuroscience & biobehavioral reviews, 96, pp. 316-334. Elsevier 10.1016/j.neubiorev.2018.11.008
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Borderline Personality Disorder (BPD) has been associated with altered hypothalamic-pituitary-adrenal (HPA) axis functioning. However, evidence is inconsistent. Therefore, the present series of meta-analyses aimed to quantify HPA axis functioning in BPD patients based on singular and continuous cortisol assessments and measures of reactivity to pharmacological and psychosocial stress. Case-control studies comparing adult BPD patients and healthy and clinical controls were considered for inclusion. The search resulted in 804 publications, of which 37 studies (k = 81; BPD n = 803, controls n = 1092) were included. Analyses were based on random effect models using standardized mean differences. BPD patients displayed elevated continuous cortisol output and blunted cortisol following psychosocial challenges. Singular cortisol assessments and cortisol after pharmacological challenges were not significantly different. Meta-analyses were limited by inconsistent reporting in individual studies and small samples for some comparisons. Due to the debilitating nature of stress-related symptoms in BPD, more research on elevated continuous cortisol output and blunted cortisol responses to psychosocial stress is warranted.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy 04 Faculty of Medicine > University Psychiatric Services > University Hospital of Child and Adolescent Psychiatry and Psychotherapy > Research Division |
UniBE Contributor: |
Koenig, Julian, Kaess, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0149-7634 |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Chantal Michel |
Date Deposited: |
18 Dec 2019 12:13 |
Last Modified: |
05 Dec 2022 15:33 |
Publisher DOI: |
10.1016/j.neubiorev.2018.11.008 |
PubMed ID: |
30500331 |
BORIS DOI: |
10.7892/boris.135652 |
URI: |
https://boris.unibe.ch/id/eprint/135652 |
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