Distribution of serotonin positive mast cells in the intrapulmonary airways of rats

Ivanova, Ivelina G.; Tomov, Nikola S.; Dimitrov, Nikolay D.; Atanasova, Dimitrinka Y.; Sivrev, Dimitar P.; Stefanov, Ivaylo S. (2019). Distribution of serotonin positive mast cells in the intrapulmonary airways of rats. Comptes rendus de l’Academie Bulgare des Sciences, 72(2), pp. 244-249. Akademija 10.7546/CRABS.2019.02.14

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Based on the scarce information about the expression of serotonin by mast cells in normal rat lung, we aimed to describe in detail the distribution of these cells in the wall of bronchi and bronchioles, as well as in the interalveolar septa. To visualize serotonin-positive mast cells a toluidine blue staining was performed immediately after the immunohistochemical staining on the same sections. Thus, we estimated the density of mast cell in different layers of intrapulmonary airways and in alveolar parenchyma. A reduction of mast cell numbers from bronchi to bronchioles, and then to alveolar septa was detected. In conclusion, detailed information about the density of serotonin positive mast cells in the layers of the wall of intrapulmonary airways and alveolar parenchyma is presented. Our findings confirm the role of these cells as one of the main sources of serotonin, which participate in maintaining the homeostasis in the lung.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

UniBE Contributor:

Tomov, Nikola Stefanov

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1310-1331

Publisher:

Akademija

Language:

English

Submitter:

Nikola Stefanov Tomov

Date Deposited:

04 Dec 2019 16:35

Last Modified:

04 Dec 2019 16:44

Publisher DOI:

10.7546/CRABS.2019.02.14

BORIS DOI:

10.7892/boris.135704

URI:

https://boris.unibe.ch/id/eprint/135704

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