Adsorption and release kinetics of growth factors on barrier membranes for guided tissue/bone regeneration: A systematic review.

Caballé-Serrano, Jordi; Abdeslam-Mohamed, Yusra; Munar-Frau, Antonio; Kobayashi, Masako; Hernández-Alfaro, Federico; Miron, Richard (2019). Adsorption and release kinetics of growth factors on barrier membranes for guided tissue/bone regeneration: A systematic review. Archives of oral biology, 100, pp. 57-68. Elsevier Science 10.1016/j.archoralbio.2019.02.006

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Guided bone / tissue regeneration (GBR/GTR) procedures are necessary to improve conditions for implant placement. These techniques in turn can be enhanced by using growth factors (GFs) such as bone morphogenetic protein (BMP-2) and platelet-derived growth factor (PDGF) to accelerate regeneration. The aim of the present systematic review was to evaluate the GF loading and release kinetics of barrier membranes.


A total of 138 articles were screened in PubMed databases, and 31 meeting the inclusion criteria were included in the present systematic review.


All the articles evaluated bio-resorbable membranes, especially collagen or polymer-based membranes. In most studies, the retention and release kinetics of osteogenic GFs such as BMP-2 and PDGF were widely investigated. Growth factors were incorporated to the membranes by soaking and incubating the membranes in GF solution, followed by lyophilization, or mixing in the polymers before evaporation. Adsorption onto the membranes depended upon the membrane materials and additional reagents such as heparin, cross-linkers and GF concentration. Interestingly, most studies showed two phases of GF release from the membranes: a first phase comprising a burst release (about 1 day), followed by a second phase characterized by slower release. Furthermore, all the studies demonstrated the controlled release of sufficient concentrations of GFs from the membranes for bioactivities.


The adsorption and release kinetics varied among the different materials, forms and GFs. The combination of membrane materials, GFs and manufacturing methods should be considered for optimizing GBR/GTR procedures.

Item Type:

Journal Article (Review Article)


04 Faculty of Medicine > School of Dental Medicine > Department of Oral Surgery and Stomatology
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Craniomaxillofacial Surgery

UniBE Contributor:

Caballé Serrano, Jordi; Kobayashi, Masako and Miron, Richard John


600 Technology > 610 Medicine & health




Elsevier Science




Caroline Dominique Zürcher

Date Deposited:

02 Dec 2019 11:47

Last Modified:

03 Dec 2019 10:54

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Barrier membranes Growth factors Guided bone regeneration Guided tissue regeneration.




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