Hawkins, Selwynne M; Guensch, Dominik P.; Friedrich, Matthias G; Vinco, Giulia; Nadeshalingham, Gobinath; White, Michel; Mongeon, Francois-Pierre; Hillier, Elizabeth; Teixeira, Tiago; Flewitt, Jacqueline A; Eberle, Balthasar; Fischer, Kady (2019). Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease. Scientific reports, 9(1), p. 17887. Springer Nature 10.1038/s41598-019-54375-9
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An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRRHV) can provide clinically useful information. A pooled analysis of the HRRHV after 60 s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15 ± 9 bpm) had a larger HRRHV than each of the disease groups (HF: 6 ± 6, CAD: 8 ± 8, CAD+/HF+: 6 ± 4, and CAD-/HF-: 8 ± 6 bpm, p < 0.001). No significant differences were found between disease groups. The HRRHV may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy 04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Günsch, Dominik, Eberle, Balthasar, Fischer, Kady Anne |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2045-2322 |
Publisher: |
Springer Nature |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
12 Dec 2019 10:15 |
Last Modified: |
05 Dec 2022 15:33 |
Publisher DOI: |
10.1038/s41598-019-54375-9 |
PubMed ID: |
31784617 |
BORIS DOI: |
10.7892/boris.136008 |
URI: |
https://boris.unibe.ch/id/eprint/136008 |
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