Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease.

Hawkins, Selwynne M; Guensch, Dominik P.; Friedrich, Matthias G; Vinco, Giulia; Nadeshalingham, Gobinath; White, Michel; Mongeon, Francois-Pierre; Hillier, Elizabeth; Teixeira, Tiago; Flewitt, Jacqueline A; Eberle, Balthasar; Fischer, Kady (2019). Hyperventilation-induced heart rate response as a potential marker for cardiovascular disease. Scientific reports, 9(1), p. 17887. Springer Nature 10.1038/s41598-019-54375-9

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An increase of heart rate to physical or mental stress reflects the ability of the autonomous nervous system and the heart to respond adequately. Hyperventilation is a user-controlled breathing maneuver that has a significant impact on coronary function and hemodynamics. Thus, we aimed to investigate if the heart rate response to hyperventilation (HRRHV) can provide clinically useful information. A pooled analysis of the HRRHV after 60 s of hyperventilation was conducted in 282 participants including healthy controls; patients with heart failure (HF); coronary artery disease (CAD); a combination of both; or patients suspected of CAD but with a normal angiogram. Hyperventilation significantly increased heart rate in all groups, although healthy controls aged 55 years and older (15 ± 9 bpm) had a larger HRRHV than each of the disease groups (HF: 6 ± 6, CAD: 8 ± 8, CAD+/HF+: 6 ± 4, and CAD-/HF-: 8 ± 6 bpm, p < 0.001). No significant differences were found between disease groups. The HRRHV may serve as an easily measurable additional marker of cardiovascular health. Future studies should test its diagnostic potential as a simple, inexpensive pre-screening test to improve patient selection for other diagnostic exams.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic and Policlinic for Anaesthesiology and Pain Therapy
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology

UniBE Contributor:

Günsch, Dominik; Eberle, Balthasar and Fischer, Kady Anne


600 Technology > 610 Medicine & health




Springer Nature




Maria de Fatima Henriques Bernardo

Date Deposited:

12 Dec 2019 10:15

Last Modified:

15 Dec 2019 02:45

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