Is It Safe to Irradiate the Newest Generation of Ventricular Assist Devices? A Case Report and Systematic Literature Review.

Spano, Giancarlo; Stutz, Emanuel; Eliçin, Olgun; Hugi, Beate; Henzen, Dominik; Fürholz, Monika; Wieser, Monika; Rhyner, Daniel Kaspar; Dobner, Stephan; Pavlicek-Bahlo, Maryam; Robson, Desiree; Nadel, James; Hayward, Christopher; Hunziker, Lukas; Martinelli, Michele; Schnegg, Bruno (2020). Is It Safe to Irradiate the Newest Generation of Ventricular Assist Devices? A Case Report and Systematic Literature Review. Artificial organs, 44(5), pp. 449-456. Wiley-Blackwell 10.1111/aor.13612

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An increasing number of mechanical assist devices, especially Left Ventricular Assist Devices (VAD), are being implanted for prolonged periods and as destination therapy. Some VAD patients require radiotherapy due to concomitant oncologic morbidities, including thoracic malignancies. This raises the potential of VAD malfunction via radiation-induced damage. So far, only case reports and small case series on radiotherapy have been published; most of them on HeartMate IITM (HMII, Abbott, North Chicago, IL, USA). Significantly, the effects of irradiation on the HeartMate 3TM (HM3, Abbott, North Chicago, IL, USA) remain undefined, despite the presence of controller components engineered within the pump itself. We report the first case of a patient with a HM3 who successfully underwent stereotactic hypo-fractionated radiotherapy due to an early stage non-small-cell lung cancer. The patient did not suffer from any complications; including toxicity or VAD malfunction. Based on this case report and on published literature, we think that performing radiotherapy after VAD implantation with the aid of a multidisciplinary team could be performed, but more in-vitro and cases series are needed to reinforce this statement.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Cardiovascular Disorders (DHGE) > Clinic of Cardiology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology > Medical Radiation Physics
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Spano, Giancarlo; Stutz, Emanuel; Eliçin, Olgun; Henzen, Dominik; Fürholz, Monika; Wieser, Monika; Rhyner, Daniel Kaspar; Dobner, Stephan; Pavlicek-Bahlo, Maryam; Hunziker Munsch, Lukas Christoph; Martinelli, Michele and Schnegg, Bruno

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0160-564X

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

18 Dec 2019 16:01

Last Modified:

18 Apr 2020 01:31

Publisher DOI:

10.1111/aor.13612

PubMed ID:

31769042

Uncontrolled Keywords:

HeartMate 3TM Non-small-cell lung cancer Radiotherapy Ventricular assist device

BORIS DOI:

10.7892/boris.136135

URI:

https://boris.unibe.ch/id/eprint/136135

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