Role of complement in diabetes.

Ajjan, Ramzi A; Schroeder, Verena (2019). Role of complement in diabetes. Molecular immunology, 114, pp. 270-277. Elsevier 10.1016/j.molimm.2019.07.031

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Accumulating evidence suggests a role for the complement system in the pathogenesis of diabetes and the vascular complications that characterise this condition. Complement proteins contribute to the development of type 1 diabetes (T1D) by enhancing the underlying organ-specific autoimmune processes. Complement upregulation and activation is also an important feature of insulin resistance and the development of type 2 diabetes (T2D). Moreover, animal and human studies indicate that complement proteins are involved in the pathogenic mechanisms leading to diabetic microvascular and macrovascular complications. The adverse vascular effects of complement appear to be related to enhancement of the inflammatory process and the predisposition to a thrombotic environment, eventually leading to vascular occlusion. Complement proteins have been considered as therapeutic targets to prevent or treat vascular disease but studies have been mainly conducted in animal models, while human work has been both limited and inconclusive so far. Further studies are needed to understand the potential role of complement proteins as therapeutic targets for reversal of the pathological processes leading to T1D and T2D and for the prevention/treatment of diabetic vascular complications.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Experimentelle Hämostase
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

Schröder, Verena

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0161-5890

Publisher:

Elsevier

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

17 Dec 2019 14:09

Last Modified:

17 Dec 2019 14:09

Publisher DOI:

10.1016/j.molimm.2019.07.031

PubMed ID:

31400630

Uncontrolled Keywords:

Complement system Diabetes Diabetic vascular complications

BORIS DOI:

10.7892/boris.136260

URI:

https://boris.unibe.ch/id/eprint/136260

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