The Genomics of Prostate Cancer: A Historic Perspective.

Rubin, Mark A.; Demichelis, Francesca (2019). The Genomics of Prostate Cancer: A Historic Perspective. Cold Spring Harbor perspectives in medicine, 9(3) Cold Spring Harbor Laboratory Press 10.1101/cshperspect.a034942

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The genomics of prostate cancer (PCA) has been difficult to study compared with some other cancer types for a multitude of reasons, despite significant efforts since the early 1980s. Overcoming some of these obstacles has paved the way for greater insight into the genomics of PCA. The advent of high-throughput technologies coming from the initial use of microsatellite and oligonucleotide probes gave rise to techniques like comparative genomic hybridization (CGH). With the introduction of massively parallel genomic sequencing, referred to as next-generation sequencing (NGS), a deeper understanding of cancer genomics in general has occurred. Along with these technologic advances, there has been the development of computational biology and statistical approaches to address novel large data sets characterized by single base resolution. This review will provide a historic perspective of PCA genomics with an emphasis on the cardinal mutations and alterations observed to be consistently seen in PCA for both hormone-naïve localized PCA and castration-resistant prostate cancer (CRPC). There will be a focus on alterations that have the greatest potential to play a role in disease progression and therapy management.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Präzisionsonkologie

UniBE Contributor:

Rubin, Mark Andrew and Demichelis, Francesca

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2157-1422

Publisher:

Cold Spring Harbor Laboratory Press

Language:

English

Submitter:

Marla Rittiner

Date Deposited:

19 Dec 2019 14:23

Last Modified:

19 Dec 2019 14:23

Publisher DOI:

10.1101/cshperspect.a034942

PubMed ID:

29712681

URI:

https://boris.unibe.ch/id/eprint/136287

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