Solberg, Yasmin; Dysli, Chantal; Escher, Pascal; Berger, Lisa; Wolf, Sebastian; Zinkernagel, Martin S. (2020). Fluorescence Lifetime Patterns of Retinal Pigment Epithelium Atrophy in Patients with Stargardt Disease and Age-Related Macular Degeneration. Ophthalmologica, 243(3), pp. 195-206. Karger 10.1159/000503567
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PURPOSE
To investigate whether autofluorescence lifetime patterns within retinal pigment epithelium (RPE) atrophy differ between age-related macular degeneration (AMD) and Stargardt disease (STGD).
METHODS
Mean retinal autofluorescence lifetimes were measured in a short and a long spectral channel (SSC: 498-560 nm; LSC: 560-720 nm). Mean retinal fluorescence lifetimes were analyzed with corresponding clinical features, fundus images, fundus autofluorescence intensity images, and optical coherence tomography. Mean fluorescence lifetime values of atrophic areas were compared between the two cohorts and within the same patient to adjacent nonatrophic regions.
RESULTS
Mean fluorescence lifetimes within areas with RPE atrophy of 13 patients with STGD (mean age ± SEM 43.7 ± 5 years) and 30 patients with geographic atrophy (mean age: 78 ± 2 years) were analyzed and compared to age-matched healthy participants. The mean area of RPE atrophy in STGD and AMD was 6.6 ± 2.3 mm2 (range: 0.66-33.17 mm2) and 17.5 ± 3.8 mm2 (range: 0.58-50.02 mm2), respectively. In patients with AMD, atrophic areas revealed significantly longer mean fluorescence lifetime values as compared with patients with STGD (SSC: 997 ± 60 vs. 363 ± 26 ps; LSC: 880 ± 46 vs. 393 ± 23 ps; p < 0.0001).
CONCLUSIONS
This study established that RPE atrophy in patients secondary to STGD and AMD display distinctive mean fluorescence lifetime characteristics. As retinal fluorescence lifetimes within areas of RPE atrophy were significantly longer in AMD patients, the analysis of specific lifetime patterns may provide additional insight into the disease processes and the pathogenetic mechanisms in the development of atrophic patches in AMD and STGD.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology |
UniBE Contributor: |
Solberg, Yasmin Samira, Dysli, Chantal-Simone, Escher, Pascal, Wolf, Sebastian (B), Zinkernagel, Martin Sebastian |
Subjects: |
600 Technology > 610 Medicine & health 500 Science > 570 Life sciences; biology |
ISSN: |
0030-3755 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Martin S. Zinkernagel |
Date Deposited: |
17 Dec 2019 12:52 |
Last Modified: |
20 Sep 2023 15:01 |
Publisher DOI: |
10.1159/000503567 |
PubMed ID: |
31743906 |
Uncontrolled Keywords: |
Age-related macular degeneration Atrophy Fluorescence lifetime imaging ophthalmoscopy Fluorescence lifetimes Stargardt disease |
BORIS DOI: |
10.48350/136323 |
URI: |
https://boris.unibe.ch/id/eprint/136323 |
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