Cross-section measurement of ⁴⁴Sc, ⁴⁷Sc, ⁴⁸Sc and ⁴⁷Ca for an optimized ⁴⁷Sc production with an 18 MeV medical PET cyclotron

Braccini, Saverio; Carzaniga, Tommaso Stefano (2019). Cross-section measurement of ⁴⁴Sc, ⁴⁷Sc, ⁴⁸Sc and ⁴⁷Ca for an optimized ⁴⁷Sc production with an 18 MeV medical PET cyclotron. Applied radiation and isotopes, 143, pp. 18-23. Elsevier 10.1016/j.apradiso.2018.10.015

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Novel medical radioisotopes for both diagnostic and therapy are essential for the future development of personalized nuclear medicine. Among them, radiometals can be used to label both proteins and peptides and encompass promising theranostic pairs. The optimized supply of radiometals in quantity and quality for clinical applications represents a scientific and technological challenge. ⁴⁷Sc is a β− emitter that forms a theranostic pair together with one of the β+ emitters ⁴³Sc or ⁴⁴Sc. It can be produced at a medical cyclotron by proton bombardment of an enriched calcium oxide target. The parasite production of ⁴⁸Sc undermines the ⁴⁷Sc purity, which strongly depends on the energy of protons impinging the target and on the thickness of the target material. For this purpose, an accurate knowledge of the production cross-sections is mandatory. In this paper, we report on the measurement of the cross-section of the reactions ⁴⁴Ca(p,n)⁴⁴mSc,⁴⁸Ca(p,n)⁴⁸Sc, ⁴⁸Ca(p,2n)⁴⁷Sc and ⁴⁸Ca(p,pn)⁴⁷Ca using natCaCO₃ targets performed at the Bern University Hospital cyclotron laboratory. On the basis of the obtained results and of the isotopic composition of commercially available enriched target materials, the thick target yields and the purity were calculated to assess the optimal irradiation conditions.

Item Type:

Journal Article (Original Article)


08 Faculty of Science > Physics Institute > Laboratory for High Energy Physics (LHEP)
10 Strategic Research Centers > Albert Einstein Center for Fundamental Physics (AEC)

UniBE Contributor:

Braccini, Saverio, Carzaniga, Tommaso Stefano


500 Science > 530 Physics








Saverio Braccini

Date Deposited:

17 Dec 2019 12:02

Last Modified:

05 Dec 2022 15:33

Publisher DOI:





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