Angiogenic profiling in HELLP syndrome cases with or without hypertension and proteinuria.

Trottmann, Fabienne; Baumann, Marc; Amylidi-Mohr, Sofia; Surbek, Daniel; Risch, Lorenz; Mosimann, Beatrice; Raio, Luigi (2019). Angiogenic profiling in HELLP syndrome cases with or without hypertension and proteinuria. European journal of obstetrics & gynecology and reproductive biology, 243, pp. 93-96. Elsevier 10.1016/j.ejogrb.2019.10.021

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OBJECTIVES Angiogenic profiling with the use of sFlt-1/PlGF ratio (soluble fms-like tyrosine kinase-1/placental growth factor) can be helpful to characterize women with signs of impending preeclampsia (PE). However, little is known about the angiogenic profile of pregnancies complicated by HELLP syndrome. The aim of this study was to examine the relationship of angiogenic profiles in cases of HELLP syndrome with and without classical signs of preeclampsia. STUDY DESIGN The angiogenic profile of pregnant women with singleton gestation and isolated PE (group 1), PE associated with HELLP syndrome (group 2), and isolated HELLP syndrome (group 3) from 01/2011 to 03/2018, were compared. To overcome gestational age dependent angiogenic behavior, cases (group 3) were matched 1:2 with cases from group 1 and 2. Matching criteria was gestational age (±1 week). PE and HELLP syndrome were defined according to the international Society for the Study of Hypertension in Pregnancy (ISSHP) statement 2014. RESULTS During the observational period, 244 women could be included in the study. Of those, 237 (97.1%) were diagnosed with PE. In 42 cases (17.2%) PE was associated with HELLP syndrome while 7 (2.9%) patients were diagnosed with isolated HELLP syndrome. Angiogenic profiles in terms of sFlt-1/PlGF ratios differed significantly between the three groups, showing highest levels in group 2 (PE/HELLP) while cases with isolated HELLP demonstrated the lowest ratios and sFlt-1 values (p = 0.01). CONCLUSION We conclude that isolated HELLP syndrome is rare and seems to be a particular entity expressing a different angiogenic behaviour compared to classical PE or PE associated with HELLP syndrome.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Trottmann, Fabienne; Baumann, Marc; Amylidi, Sofia Kalypso; Surbek, Daniel; Mosimann, Beatrice and Raio, Luigi


600 Technology > 610 Medicine & health








Monika Zehr

Date Deposited:

24 Dec 2019 09:25

Last Modified:

24 Dec 2019 09:25

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Angiogenic profiling HELLP syndrome Preeclampsia




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