Systemic Inflammation in Pregnant Women With Periodontitis and Preterm Prelabor Rupture of Membranes: A Prospective Case-Control Study.

Mohr, Stefan; Amylidi-Mohr, Sofia K; Stadelmann, Pascale; Sculean, Anton; Persson, Rutger; Eick, Sigrun; Surbek, Daniel (2019). Systemic Inflammation in Pregnant Women With Periodontitis and Preterm Prelabor Rupture of Membranes: A Prospective Case-Control Study. Frontiers in immunology, 10, p. 2624. Frontiers Research Foundation 10.3389/fimmu.2019.02624

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Aims: Periodontal disease is associated with adverse pregnancy outcome, but the underlying pathophysiologic mechanism is still unknown. In this prospective, longitudinal, non-interventional case-control study, 45 women with preterm premature rupture of membranes and 26 controls with uncomplicated pregnancies were examined at three time-points (T1: 20-34 weeks of gestations; T2: within 48 h after delivery; T3: 4-6 weeks post partum). Examinations included subgingival, blood, vaginal, and placenta sampling for microbiologic, cytokine, and histology assessment. Objective of this study was to test the hypothesis that systemic inflammatory changes and not specific bacteria are predominantly involved in the association between periodontal disease and adverse pregnancy outcome. Results: Demographic data and gestational age at T1 were comparable between groups. While there was no correlation between vaginal and gingival fluid microbiome, cytokine levels in the assessed compartments differed between cases, and controls. Vaginal smears did not show a higher rate of abnormal flora in the cases at the onset of preterm premature rupture of membranes. Number and variety of bacteria in the case group placental membranes and vagina were higher, but these bacteria were not found in membranes at birth. Conclusions: On the basis of our results we speculate that an inflammatory pathway sequentially involving periodontal tissue, maternal serum, and finally vaginal compartment contributes to the underlying pathomechanism involved in preterm premature rupture of membranes associated with periodontitis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > School of Dental Medicine, Periodontics Research
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Mohr, Stefan; Amylidi, Sofia Kalypso; Sculean, Anton; Eick, Sigrun and Surbek, Daniel

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1664-3224

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Monika Zehr

Date Deposited:

12 Dec 2019 12:19

Last Modified:

15 Dec 2019 02:46

Publisher DOI:

10.3389/fimmu.2019.02624

PubMed ID:

31787985

Uncontrolled Keywords:

PPROM adverse pregnancy outcome cytokines inflammatory mediators periodontal inflammation periodontopathogenic bacteria preterm birth preterm premature rupture of membranes

BORIS DOI:

10.7892/boris.136514

URI:

https://boris.unibe.ch/id/eprint/136514

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