Stadler, A; Weidlinger, Susanna; Stute, Petra (2019). Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review. Climacteric, 22(5), pp. 435-441. Taylor & Francis 10.1080/13697137.2019.1622085
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Stress activates the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPAA). Based on a systematic literature review of the impact of endogenous and exogenous exposure with natural progesterone on the stress response in healthy premenopausal and postmenopausal women, the following conclusions can be drawn: the HPAA activity was not relevantly affected by endogenous progesterone exposure across the menstrual cycle, but might be reduced by exogenous micronized progesterone application; in contrast, the ANS has a sympathetic predominance in the (progesterone-dominated) luteal phase of the menstrual cycle. Future studies should assess various stress biomarkers under various hormonal conditions to, for example, allow for cardiovascular risk stratification in hormone users.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology |
UniBE Contributor: |
Weidlinger, Susanna, Stute, Petra |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1369-7137 |
Publisher: |
Taylor & Francis |
Language: |
English |
Submitter: |
Monika Zehr |
Date Deposited: |
12 Dec 2019 10:53 |
Last Modified: |
05 Dec 2022 15:33 |
Publisher DOI: |
10.1080/13697137.2019.1622085 |
PubMed ID: |
31267780 |
Uncontrolled Keywords: |
Heart rate variability cortisol hypothalamic–pituitary–adrenal axis menopausal hormone therapy menopause menstrual cycle progesterone |
BORIS DOI: |
10.7892/boris.136544 |
URI: |
https://boris.unibe.ch/id/eprint/136544 |
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