Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review.

Stadler, A; Weidlinger, Susanna; Stute, Petra (2019). Impact of endogenous and exogenous progesterone exposure on stress biomarkers: a systematic review. Climacteric, 22(5), pp. 435-441. Taylor & Francis 10.1080/13697137.2019.1622085

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Stress activates the autonomic nervous system (ANS) and the hypothalamic-pituitary-adrenal axis (HPAA). Based on a systematic literature review of the impact of endogenous and exogenous exposure with natural progesterone on the stress response in healthy premenopausal and postmenopausal women, the following conclusions can be drawn: the HPAA activity was not relevantly affected by endogenous progesterone exposure across the menstrual cycle, but might be reduced by exogenous micronized progesterone application; in contrast, the ANS has a sympathetic predominance in the (progesterone-dominated) luteal phase of the menstrual cycle. Future studies should assess various stress biomarkers under various hormonal conditions to, for example, allow for cardiovascular risk stratification in hormone users.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

UniBE Contributor:

Weidlinger, Susanna and Stute, Petra

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1369-7137

Publisher:

Taylor & Francis

Language:

English

Submitter:

Monika Zehr

Date Deposited:

12 Dec 2019 10:53

Last Modified:

12 Dec 2019 10:53

Publisher DOI:

10.1080/13697137.2019.1622085

PubMed ID:

31267780

Uncontrolled Keywords:

Heart rate variability cortisol hypothalamic–pituitary–adrenal axis menopausal hormone therapy menopause menstrual cycle progesterone

BORIS DOI:

10.7892/boris.136544

URI:

https://boris.unibe.ch/id/eprint/136544

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