Melanoma of the nail apparatus: a systematic review and meta-analysis of current challenges and prognosis.

Lieberherr, Sven; Cazzaniga, Simone; Haneke, Eckart; Hunger, Robert E.; Seyed Jafari, S. Morteza (2020). Melanoma of the nail apparatus: a systematic review and meta-analysis of current challenges and prognosis. Journal of the European Academy of Dermatology and Venereology : JEADV, 34(5), pp. 967-976. Wiley 10.1111/jdv.16121

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Nail apparatus melanoma (NAM) is a rare dermatologic malignancy. Its prognosis is poor because it is often diagnosed late. However, progression and survival of NAM patients have only been studied among small populations. Early biopsy could help to identify suspicious lesions at a less invasive stage. While surgery is generally seen as the treatment of choice, the extent of excision margins and the use of sentinel biopsy remain debated. This systematic review aims to summarize the treatment procedures and observed prognosis in the literature during the last two decades and present pooled survival and progression rates of NAM by using meta-analysis. A systematic review on studies assessing pathology, treatment and prognosis of NAM was carried out up to end of 2018. After evaluation of eligible studies, the main emerging topics were outlined and pooled survival outcomes estimated. A total of 30 articles out of 624 identified records were included for systematic review. Finally, meta-analysis of pooled mortality rates including 18 studies was 4.6 x 100 patent-years (95% CI: 2.7, 6.8) equivalent to 5-year cumulative survival of 77.0%. Additionally, the pooled progression rate based on 17 studies was 6.3 x 100 patent-years (95% CI: 4.1, 8.9) with estimated 5-year cumulative progression-free survival of 68.5%.While the optimal extent of surgical treatment remains debated, prompt biopsy could help to identify early lesions. This is the first study to present pooled survival and progression rates by meta-analysis.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Cazzaniga, Simone; Haneke, Eckart; Hunger, Robert and Jafari, Morteza

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1468-3083

Publisher:

Wiley

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

13 Dec 2019 16:29

Last Modified:

24 May 2020 01:31

Publisher DOI:

10.1111/jdv.16121

PubMed ID:

31788861

Uncontrolled Keywords:

Melanoma Meta-analysis Nail apparatus Prognosis Survival

BORIS DOI:

10.7892/boris.136749

URI:

https://boris.unibe.ch/id/eprint/136749

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