Recurrent Eczema Herpeticum - A Retrospective European Multicenter Study Evaluating the Clinical Characteristics of Eczema Herpeticum Cases in Atopic Dermatitis Patients.

Seegräber, Marlene; Worm, Margitta; Werfel, Thomas; Svensson, Ake; Novak, Natalija; Simon, Dagmar; Darsow, Ulf; Augustin, Matthias; Wollenberg, Andreas (2020). Recurrent Eczema Herpeticum - A Retrospective European Multicenter Study Evaluating the Clinical Characteristics of Eczema Herpeticum Cases in Atopic Dermatitis Patients. Journal of the European Academy of Dermatology and Venereology : JEADV, 34(5), pp. 1074-1079. Wiley 10.1111/jdv.16090

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BACKGROUND

Eczema herpeticum (EH) is a disseminated viral infection of eczematous skin disease with the herpes simplex virus. Knowledge on clinical characteristics, risk factors and recurrent disease is limited. Our aim was to better define clinical characteristics and risk factors for EH and especially for recurrent EH.

METHODS

A retrospective analysis of EH cases assessed the history, clinical signs, prior treatment and laboratory results using a predefined questionnaire.

RESULTS

A total of 224 EH cases from 8 European centers were included. Extrinsic AD was identified as risk factor for EH, only one patient suffered from intrinsic AD. Early-onset of AD was identified as risk factor for recurrent EH. Pre-treatment with topical steroids, systemic steroids, topical calcineurin inhibitors or plain emollients reflected standard therapy. Many patients showed AD lesions without EH, but skin without AD lesions was never affected by herpetic lesions.

CONCLUSION

Patients with clinically active, extrinsic AD are at risk for EH. Recurrent EH is associated with confounders of severe atopic distortion, and requires active AD lesions for clinical manifestation. Recurrent eczema herpeticum mainly affects patients with early onset of AD.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology

UniBE Contributor:

Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1468-3083

Publisher:

Wiley

Language:

English

Submitter:

Sandra Nyffenegger

Date Deposited:

30 Dec 2019 08:09

Last Modified:

17 Nov 2020 02:30

Publisher DOI:

10.1111/jdv.16090

PubMed ID:

31733162

Uncontrolled Keywords:

Eczema herpeticum atopic dermatitis distribution extrinsic recurrence

BORIS DOI:

10.7892/boris.136767

URI:

https://boris.unibe.ch/id/eprint/136767

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