Structure and function of a monocarboxylate transporter homolog specific for L-lactate.

Bosshart, Patrick; Kalbermatter, David; Bonetti, Sara; Fotiadis, Dimitrios (2019). Structure and function of a monocarboxylate transporter homolog specific for L-lactate. Molecular & cellular oncology, 6(6), e1646605. Taylor & Francis 10.1080/23723556.2019.1646605

[img]
Preview
Text
Structure.pdf - Published Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

Monocarboxylate transporters play important roles in certain cancers. We have reported structures of an L-lactate-transporting solute carrier family 16 homolog with bound substrate and inhibitor. The structures show the transporter in the pharmacologically relevant outward-open conformation. Structure-function analysis provides insights into the molecular working mechanisms of ligand binding and L-lactate transport.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Faculty Institutions > NCCR TransCure
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine

UniBE Contributor:

Bosshart, Patrick; Kalbermatter, David; Bonetti, Sara and Fotiadis, Dimitrios José

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

2372-3556

Publisher:

Taylor & Francis

Language:

English

Submitter:

Barbara Järmann-Bangerter

Date Deposited:

23 Dec 2019 15:02

Last Modified:

23 Dec 2019 15:02

Publisher DOI:

10.1080/23723556.2019.1646605

PubMed ID:

31692891

Uncontrolled Keywords:

L-lactate transporter SLC16 family monocarboxylate transporter structure transport mechanism

BORIS DOI:

10.7892/boris.136805

URI:

https://boris.unibe.ch/id/eprint/136805

Actions (login required)

Edit item Edit item
Provide Feedback