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(e) -5 (e) -4.9 (din) 8 (g) -3 (\056 LPV\057r in v) -3 (i) 12 (t) -5 (r) 13 (o e\037) 9 (e) -4.9 (c) -7 (t o) 12 (n s) 5 (t) 6 (er) 13 (o) 12 (idog) 8 (en) 4 (esi) 3 (s wa) 3 (s a) 3 (s) 5.1 (s) -8 (es) 5 (s) -8 (e) -5 (d in H295R ce) 4 (l) -5 (l) 3 (s\056) ] TJ /T1_6 1 Tf 0.005 Tc -0.005 Tw 1 -1.263 Td [ (Re) -3 (s) 8 (ul) 10.1 (ts\056) ] TJ /T1_1 1 Tf 0.112 Tw /Span << /ActualText (\376\377 \003) >> BDC ( ) Tj EMC 4.191 0 Td [ (A) 41 (t w) 8 (e) -5 (e) 4 (k 6\054 159 f) -10 (r) 13 (o) 6 (zen p) 7 (l) -3 (a) 3 (sm) 3 (a s) -6 (a) 9 (m) 19 (p) 7 (les f) -10 (r) 13 (o) 12 (m B) 7 (ur) 4.1 (k) -4 (in) 3 (a F) 20 (a) 3 (s) -8 (o a) 9 (n) 4 (d S) -14 (o) 11 (u) 12.1 (t) -6 (h A) 3 (f) -10 (r) -6 (ic) -2.9 (a w) 8 (er) 13 (e a) 3 (s) 5 (s) -8 (es) 5 (s) -7.9 (e) -5 (d \050LPV\057r g) -5 (r) 13 (o) 11 (u) 12 (p\072 n \075 92\073) 5 ( ) ] TJ 0.028 Tw -5.191 -1.263 Td [ (3T) 8 (C g) -5 (r) 13 (o) 11 (u) 12 (p\072 n \075 67\051 a) 9 (n) 4 (d a) 19 (t w) 8 (e) -5 (e) 4 (k 26\054 95 s) -5.9 (a) 8.9 (m) 19.1 (p) 7 (les f) -9.9 (r) 13 (o) 12 (m B) 7 (ur) 4 (k) -3.9 (in) 3 (a F) 20 (a) 3 (s) -8 (o \050LPV\057r g) -5 (r) 13 (o) 11 (u) 12 (p\072 n \075 47\073 3T) 8 (C g) -5 (r) 13 (o) 11 (u) 12 (p\072 n \075 48\051\056 A) 41 (t w) 8 (e) -5 (e) 4.1 (k 6\054 LPV\057r) 24 (\055) ] TJ -0.033 Tw T* [ (t) -5 (r) 13 (e) -6 (a) 19.1 (t) 6 (e) -5 (d ) 0.5 (infa) 9 (n) 19 (ts h) 3 (ad ) 0.5 (a ) 0.5 (hig) -7 (h) 4 (er ) 0.5 (m) 4 (e) -5 (di) -3 (a) 9 (n ) 0.5 (de) 4 (h) 23 (y) 8.1 (dr) 13 (o) -9 (ep) 12 (i) -3 (a) 9 (n) 4 (dr) 13 (os) 5 (t) 6 (er) 13 (o) 12 (n) 4 (e ) 0.5 (\050D) 9 (HEA\051 ) 0.5 (le) -8 (v) 8 (e) 4 (l ) 0.5 (t) -5.9 (h) 3 (a) 8.9 (n ) 0.5 (infa) 9 (n) 19 (ts ) 0.5 (f) -10 (r) 13 (o) 12.1 (m ) 0.5 (t) -6 (h) 4 (e ) 0.5 (3T) 8 (C ) 0.5 (a) 9 (r) -6 (m\072 ) 0.5 (3\05691 ) 0.5 (v) 8 (er) 6 (s) 5 (u) 3.1 (s 1\05648 ) 0.5 (n) 8 (g\057mL) 5 ( ) ] TJ 0 Tc 0 Tw 52.189 0 Td ( ) Tj -52.189 -1.263 Td (\050) Tj /T1_7 1 Tf 0.351 0 Td (P) Tj /T1_1 1 Tf 0.005 Tc 0.092 Tw 0.559 0 Td [ ( \074\035) -91.8 (\056001\051\056 H) 16 (ig) -7 (h) 4 (er D) 9 (HEA le) -7.9 (v) 7.9 (e) 4.1 (l) 3 (s \050\0765 n) 8 (g\057mL\051 a) 19 (t w) 8 (e) -5 (e) 4.1 (k 6 w) 8 (er) 13 (e a) 3 (s) 5 (s) -7.9 (o) -9 (ci) -3 (a) 19 (t) 6 (e) -4.9 (d w) -3 (i) 12 (t) -6 (h hig) -6.9 (h) 4 (er 17\055O) 8.9 (H\055p) 12 (r) 13 (eg) -5 (n) 4 (en) 4 (o) 7 (lo) 12 (n) 4 (e \0507\05678 vs 3\05671 n) 8 (g\057mL\054) 5 ( ) ] TJ 0 Tc 0 Tw 51.28 0 Td ( ) Tj /T1_7 1 Tf -52.189 -1.263 Td (P) Tj /T1_1 1 Tf 0.005 Tc 0.029 Tw 0.559 0 Td [ ( \075 \0560004\051 a) 9 (n) 4 (d lo) 16 (w) 8 (er t) 6 (es) 5.1 (t) 6 (os) 5 (t) 6 (er) 13 (o) 12 (n) 4 (e \0500\05605 vs 1\05634 n) 8 (g\057mL\054 ) ] TJ /T1_7 1 Tf 0 Tc 0 Tw (P) Tj /T1_1 1 Tf 0.005 Tc 0.029 Tw 22.421 0 Td [ ( \075 \056009\051 le) -8 (v) 8 (e) 4 (l) 3 (s in LPV\057r) 24 (\055exp) -9 (os) -8 (e) -4.9 (d c) 6 (hi) -5 (ldr) 13 (en\056 \034) 4 (er) 13 (e wa) 3 (s a sig) -4.9 (ni\036c) -3 (a) 9 (n) 19 (t co) 12 (r) -6 (r) 13 (e) ] TJ 0 Tc 0 Tw (\055) Tj 0.005 Tc 0.016 Tw -22.98 -1.263 Td [ (l) -3 (a) 19 (t) -5 (io) 12 (n b) -9 (et) -3 (w) 8 (e) -4.9 (en t) -6 (h) 4 (e D) 9 (HEA a) 9 (n) 4 (d LPV\057r A) 58 (UC le) -8 (v) 8 (e) 4 (l) 3.1 (s \050\033 \075 0\05640\054 ) ] TJ /T1_7 1 Tf 0 Tc 0 Tw (P) Tj /T1_1 1 Tf 0.005 Tc 0.016 Tw 24.704 0 Td [ ( \075 \056019\051 a) 9 (n) 4 (d C) ] TJ -0.008 Tc 0.008 Tw 5.5385 0 0 5.5385 338.7834 397.2097 Tm [ (t) -18 (ro) -2 (u) -13 (g) -19.9 (h) ] TJ 0.005 Tc 0.016 Tw 9.5 0 0 9.5 353.942 400.3732 Tm ( \050\033 \075 0\05640\054 ) Tj /T1_7 1 Tf 0 Tc 0 Tw (P) Tj /T1_1 1 Tf 0.005 Tc 0.016 Tw 4.916 0 Td [ ( \075 \056017\051\056 A) 41 (t w) 8 (e) -4.9 (e) 4 (k 26\054 D) 9 (HEA le) -7.9 (v) 8 (e) 4 (l) 3 (s r) 13 (e) ] TJ 0 Tc 0 Tw (\055) Tj 0.005 Tc -0.04 Tw -37.004 -1.263 Td [ (m) 3 (a) 9 (in) 4 (e) -5 (d hig) -6.9 (h) 4 (er in t) -5.9 (h) 4 (e LPV\057r a) 9 (r) -6 (m\072 0\05645 v) 8 (er) 6 (s) 5 (u) 3 (s 0\05613 n) 8 (g\057mL \050) ] TJ /T1_7 1 Tf 0 Tc 0 Tw (P) Tj /T1_1 1 Tf 0.005 Tc -0.04 Tw 23.648 0 Td [ ( \075 \056002\051\056 L) -8.9 (o) 11 (p) 12 (in) 3 (a) 18 (v) -3 (ir) 63 (\054 b) 11 (u) 12 (t n) 4 (o) 11 (t r) -5.9 (i) 12 (t) 6 (o) 12 (n) 3 (a) 18 (v) -3 (ir) 63 (\054 in) -5 (hi) 4 (b) 12 (i) 12 (t) 6.1 (e) -5 (d CYP17A1 a) 9 (n) 4 (d CYP21A2) 5 ( ) ] TJ 0 Tw -23.648 -1.263 Td [ (ac) -7 (t) -5 (i) 7.1 (v) -3 (i) 12 (t) -3 (y in H295R ce) 4 (l) -5 (l) 3 (s\056) ] TJ /T1_6 1 Tf -0.005 Tc 0.005 Tw 1 -1.263 Td [ (C) -9 (o) -2 (nc) 4 (lu) -18 (s) 3 (i) -8 (o) -2 (n) -17 (s) -5 (\056) ] TJ /T1_1 1 Tf 0 Tc 0.007 Tw /Span << /ActualText (\376\377 \003) >> BDC 5.216 0 Td ( ) Tj EMC 1 0 Td [ (L) -9 (o) 11 (p) 12 (in) 3 (a) 18 (v) -3 (ir wa) 3 (s a) 3 (s) 5 (s) -8 (o) -9 (ci) -2.9 (a) 19 (t) 6 (e) -5 (d w) -3 (i) 12 (t) -6 (h dos) -8 (e\055dep) -8.9 (en) 4 (den) 19 (t adr) 13 (en) 3 (a) -5 (l d) 7 (ysf) -6 (un) 4 (c) -7 (t) -5 (io) 12 (n in infa) 9 (n) 19 (ts\056 \034) 4 (e im) 19 (p) -5 (ac) -7 (t o) 12 (f lo) 12 (n) 8 (g\055t) 6 (er) -6 (m exp) -8.9 (os) 5 (ur) 13 (e ) ] TJ 0 Tw -7.216 -1.263 Td [ (a) 9 (n) 4 (d p) -9 (o) 11 (t) 6 (en) 19 (t) -5 (i) -2.9 (a) -5 (l c) 6 (linic) -2.9 (a) -5 (l co) 12 (n) 8 (s) -8 (e) -5 (q) 10.1 (uen) 4 (ces r) 13 (e) -4.9 (q) 10 (uir) 13 (e e) -8 (va) -5 (l) 12 (u) -2.9 (a) 19 (t) -5 (io) 12 (n\056) ] TJ /T1_2 1 Tf 1 -1.263 Td [ (K) 21 (e) -16 (y) -9 (w) 4 (o) 10 (r) 8 (ds\056) ] TJ /Span << /ActualText (\376\377 \003) >> BDC ( ) Tj EMC /T1_1 1 Tf 5.383 0 Td [ (HIV infa) 9 (n) 19 (t p) 12 (r) 13 (o) 11 (p) 7 (h) 23 (y) -7 (l) -3 (axi) 3 (s\073 lo) 11 (p) 12.1 (in) 3 (a) 18 (v) -3 (ir) -24 (\073 adr) 13 (en) 3 (a) -5 (l f) -5.9 (un) 4 (c) -7 (t) -5 (io) 12 (n im) 19 (p) -5 (a) 9 (ir) -6 (m) 4 (en) 19 (t\073 CYP21 a) 9 (n) 4 (d CYP17 in) -5 (hi) 4 (b) 12 (i) 12 (t) -5 (io) 12 (n\056) ] TJ 0.01 Tc 0.036 Tw -6.383 -3.053 Td [ (Th) 4 (e o) 16 (v) 8 (era) -4.9 (l) -5 (l s) -6 (a) 9 (f) 9 (et) -3 (y o) 12 (f a) 9 (n) 19 (t) -5 (ir) 13 (et) -5 (r) 13 (o) 16 (v) -3 (ira) -5 (l) 3 (s \050AR) 49 (Vs) ] TJ [ (\051 in c) 6 (hi) -5 (ldr) 13 (en li) 7 (v) -3 (in) 7.9 (g) 10 ( ) ] TJ 0.2 Tw 0 -1.368 TD [ (w) -3 (i) 12 (t) -6 (h ) 0.5 (h) 19 (um) 3 (a) 9 (n ) 0.5 (imm) 19.1 (un) 3.9 (o) -8.9 (def) -10 (icien) 4 (c) -16 (y ) 0.5 (v) -3 (ir) -9.9 (u) 3 (s ) 0.5 (\050HIV) -3 (\051 ) 0.5 (i) 3 (s ) 0.6 (c) 5.9 (los) -8 (e ) 0.5 (t) 6 (o) 29 (\054 ) 0.5 (o) 12 (r) 10 ( ) ] TJ 0.202 Tw T* [ (b) -9 (et) 10 (t) 6 (er t) -6 (h) 3 (a) 9 (n\054 t) -6 (h) 3 (a) 19 (t o) 5 (bs) -8 (er) -29 (v) 8 (e) -5 (d in ad) 12 (u) -5 (l) 12 (ts \133) ] TJ 0 0 1 rg /GS0 gs -0.01 Tw (1\2268) Tj 0 0 0 1 k /GS1 gs 0.202 Tw [ (\135\054 in w) -7 (h) 4 (o) 11.9 (m a) 4.9 (g) -4.9 (in) 8 (g) 10 ( ) ] TJ 0.08 Tw T* [ (a) 9 (n) 4 (d cer) -10 (t) -6 (a) 9 (in co) 12 (fac) -7 (t) 6 (o) 12 (r) 6 (s m) 3 (a) 18 (y a) 5 (g) -6 (g) -5 (ra) 18 (va) 19 (t) 6 (e t) -6 (h) 4 (e im) 19 (p) -5 (ac) -7 (t o) 12 (f t) -5 (r) 13 (e) -6 (a) 19 (t) -5 (m) 4 (en) 19 (t) 10 ( ) ] TJ 0 Tc 0 Tw 0 -1.368 TD (\133) Tj 0 0 1 rg /GS0 gs 0.01 Tc -0.01 Tw 0.355 0 Td (9\22611) Tj 0 0 0 1 k /GS1 gs 0.057 Tw [ (\135\056 Thi) 3 (s i) 3 (s n) 4 (o) 11 (t n) 4 (e) -5 (ces) 5 (s) -5.9 (a) 8.9 (r) -6 (i) -4.9 (l) 7 (y t) -6 (h) 4 (e c) -3 (a) 3 (s) -8 (e f) 9 (o) 11.9 (r n) 4 (e) -8 (w) -12 (b) -9 (o) 12 (r) -6 (n) 8 (s a) 9 (n) 4 (d in) ] TJ 0 Tc 0 Tw (\055) Tj 0.01 Tc -0.046 Tw -0.355 -1.368 Td [ (fa) 9 (n) 19 (ts\054 f) 9 (o) 12 (r w) -7 (h) 4 (o) 12 (m t) -6 (h) 4.1 (e imm) 3 (a) 19 (t) 10 (ur) -6 (i) 12 (t) -3 (y o) 12 (f cer) -9.9 (t) -6 (a) 8.9 (in enzy) -3 (m) 3 (a) 19 (t) -5 (ic p) 12 (r) 13 (o) -9 (ces) 5 (s) -8 (es) 10 ( ) ] TJ 0.118 Tw 0 -1.368 TD [ (i) 3 (s li) -5 (k) 9 (e) 4 (l) 7 (y t) 6 (o ) 0.5 (m) 4 (o) -9 (dif) -17 (y t) -6 (h) 4 (e m) 4 (et) -6 (a) 8 (b) -9 (o) 7 (li) 3 (sm ) 0.5 (o) 12 (f dr) -10 (ugs a) 9 (n) 4 (d t) -6 (h) 4 (eir ) 0.5 (t) 6 (o) 6.9 (ler) ] TJ 0 Tc 0 Tw 24.791 0 Td (\055) Tj 0.01 Tc 0.136 Tw -24.791 -1.368 Td [ (a) 9 (n) 4 (ce \133) ] TJ 0 0 1 rg /GS0 gs -0.01 Tw (12\22615) Tj 0 0 0 1 k /GS1 gs 0.136 Tw [ (\135\056 Thi) 3 (s a) 19 (p) 11 (p) 7 (lies t) 6 (o in) 4 (dir) 13 (e) -5 (c) -6.9 (t exp) -9 (os) 5 (ur) 13 (e t) 6 (o m) 3 (a) 19 (t) 6 (er) -6 (n) 3 (a) -5 (l) 10 ( ) ] TJ 0.018 Tw T* [ (t) -5 (r) 13 (e) -6 (a) 19 (t) -5 (m) 4 (en) 19 (t b) -9 (o) 11 (t) -6 (h in u) 12 (t) 6 (er) 13 (o a) 9 (n) 4 (d t) -6 (hr) 13 (o) 11 (ug) -7 (h b) 12 (r) 13 (e) -6 (a) 3 (s) 5 (t) -5 (f) 9 (e) -5 (e) -5 (din) 8 (g a) 9 (n) 3.9 (d dir) 13 (e) -5 (c) -7 (t) 10 ( ) ] TJ -0.022 Tw 27.042 10.947 Td [ (exp) -9 (os) 5 (ur) 13 (e) 6 (\054 s) 5 (uc) 6 (h a) 3 (s p) -8.9 (os) 5 (t) -5 (n) 3 (a) 19 (t) -6 (a) -5 (l p) 12 (r) 13 (o) 11 (p) 7 (h) 23 (y) -7 (l) -3 (axi) 3 (s g) -5 (i) 7 (v) 8 (en t) 6 (o t) -6 (h) 4 (e n) 3.9 (e) -7.9 (w) -12 (b) -9 (o) 12 (r) -6 (n\054) 10 ( ) ] TJ 0.074 Tw T* [ (a) 3 (s w) 8 (e) 4 (l) -5 (l a) 3 (s t) -5 (r) 13 (e) -5.9 (a) 19 (t) -5 (m) 4 (en) 19 (t o) 12 (f infa) 8.9 (n) 19.1 (ts w) -3 (i) 12 (t) -6 (h HIV) 144 (\054 f) 9 (o) 12 (r w) -6.9 (h) 3.9 (o) 12 (m i) 12 (t i) 3 (s n) 4 (o) 16 (w) 10 ( ) ] TJ 0.145 Tw T* [ (r) 13 (e) -5 (co) 12 (mm) 4 (en) 4 (de) -5 (d t) 5.9 (o ini) 11.9 (t) -4.9 (i) -3 (a) 19 (t) 6 (e t) -5 (r) 13 (e) -6 (a) 19 (t) -5 (m) 4 (en) 19 (t a) 3 (s e) -6 (a) 9 (r) 4 (l) 7 (y a) 3 (s p) -9 (os) 5 (si) 4 (b) 7 (le \133) ] TJ 0 0 1 rg /GS0 gs -0.01 Tw (12) Tj 0 0 0 1 k /GS1 gs 0 Tc 0 Tw (\054 ) Tj 0 0 1 rg /GS0 gs 0.01 Tc -0.01 Tw T* (16\22618) Tj 0 0 0 1 k /GS1 gs 0.089 Tw [ (\135\056 Th) 4 (e e) -7.9 (va) -5 (l) 12 (u) -3 (a) 19 (t) -5 (io) 12 (n o) 12 (f t) -6 (h) 4 (e t) 6 (o) 7 (lera) 9 (n) 4 (ce t) 6 (o dr) -9.9 (ugs ini) 12 (t) -5 (i) -3 (a) 19 (t) 6 (e) -5 (d in) 10 ( ) ] TJ 0.018 Tw 0 -1.368 TD [ (t) -6 (h) 4 (e p) -9 (er) -6 (in) 3 (a) 19 (t) -6 (a) -5 (l p) -9 (er) -6 (io) -8.9 (d i) 3 (s n) 4 (o) 11 (t s) 5 (t) -5 (ra) 9 (ig) -7 (h) 19 (t) -5 (f) 9 (o) 12 (r) -29 (wa) 9 (r) 13 (d) 6 (\054 a) 2.9 (s AR) 49 (V t) -5 (r) 13 (e) -6 (a) 19 (t) -5 (m) 4 (en) 18.9 (t) 10 ( ) ] TJ 0.18 Tw 0 -1.368 TD [ (i) 3 (s g) -5 (i) 7 (v) 8 (en a) 3 (s a co) 12 (m) 10 (b) 12 (in) 3 (a) 19 (t) -5 (io) 12 (n o) 12 (f s) -8 (e) -8 (v) 8 (era) -5 (l m) 4 (o) 7 (le) -5 (c) -6.9 (u) -5 (les o) 11.9 (f dif) -9.9 (f) 8.9 (er) 13 (en) 19 (t) 9.9 ( ) ] TJ -0.043 Tw T* [ (c) 6 (l) -3 (a) 3 (s) 5 (s) -8 (es \133) ] TJ 0 0 1 rg /GS0 gs -0.01 Tw (19) Tj 0 0 0 1 k /GS1 gs -0.043 Tw [ (\135 a) 9 (n) 4 (d t) -6 (h) 4 (e iden) 19 (t) -5 (if) -10 (ic) -3 (a) 19 (t) -4.9 (io) 12 (n a) 9 (n) 4 (d s) 5 (t) -6 (a) 19 (t) -5 (i) 3 (s) 5 (t) -5 (ic) -3 (a) -4.9 (l in) 19.1 (t) 5.9 (er) -10 (p) 12 (r) 13 (et) -6 (a) 19 (t) -5 (io) 12 (n) 10 ( ) ] TJ 0.088 Tw T* [ (o) 12 (f t) -6 (h) 4 (e in) 4 (ciden) 4 (ce o) 11.9 (f ra) 9 (r) 13 (e c) 6 (linic) -3 (a) -5 (l e) -8 (v) 8 (en) 19 (ts r) 13 (e) -4.9 (q) 9.9 (uir) 13 (e l) -3 (a) 9 (r) 8 (g) 8 (e t) -5 (r) -6 (i) -3 (a) -5 (l) 3 (s o) 12.1 (r) 9.9 ( ) ] TJ 0.063 Tw T* [ (co) 7 (h) 4 (o) 12 (r) -10 (ts\056 A\035) -62.6 (co) 12 (m) 19 (p) 7 (lem) 4 (en) 19 (t) -6 (a) 9 (r) -29 (y a) 19 (p) 11 (p) 12 (r) 13 (o) -5 (ac) 6 (h co) 11.9 (n) 8 (si) 2.9 (s) 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