Abscopal effect in lung cancer: three case reports and a concise review.

Garelli, Elena; Rittmeyer, Achim; Putora, Paul Martin; Glatzer, Markus; Dressel, Ralf; Andreas, Stefan (2019). Abscopal effect in lung cancer: three case reports and a concise review. Immunotherapy, 11(17), pp. 1445-1461. Future Medicine Ltd 10.2217/imt-2019-0105

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The abscopal effect describes the ability of locally administered radiotherapy to induce systemic antitumor effects. Over the past 40 years, reports on the abscopal effect following conventional radiation have been relatively rare, especially in less immunogenic tumors such as lung cancer. However, with the continued development and use of immunotherapy, reports on the abscopal effect have become increasingly frequent during the last decade. Here, we present three illustrative case reports from our own institution and previous published cases of the abscopal effect in patients with non-small cell lung cancer, treated with immune checkpoint inhibitors and radiotherapy. We also present a concise review of the clinical and experimental literature on the abscopal effect in non-small cell lung cancer.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Radiation Oncology

UniBE Contributor:

Putora, Paul Martin

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1750-7448

Publisher:

Future Medicine Ltd

Language:

English

Submitter:

Beatrice Scheidegger

Date Deposited:

30 Dec 2019 13:55

Last Modified:

30 Dec 2019 14:04

Publisher DOI:

10.2217/imt-2019-0105

PubMed ID:

31826745

Uncontrolled Keywords:

NSCLC abscopal effect checkpoint inhibitors immunotherapy lung cancer radiotherapy

BORIS DOI:

10.7892/boris.136875

URI:

https://boris.unibe.ch/id/eprint/136875

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