Analysis of blood degradation products and ferritin in the cerebrospinal fluid of dogs with acute thoracolumbar intervertebral disk extrusion, a prospective pilot study.

Bittermann, Sophie; Schild, Christof; Marti, Eliane; Mirkovitch, Jelena; Schweizer, Daniela; Henke, Diana (2019). Analysis of blood degradation products and ferritin in the cerebrospinal fluid of dogs with acute thoracolumbar intervertebral disk extrusion, a prospective pilot study. BMC veterinary research, 15(1), p. 148. BioMed Central 10.1186/s12917-019-1878-9

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BACKGROUND Hemorrhage in the spinal canal leads to further damage of the spinal cord influencing outcome in dogs with intervertebral disk (IVD) extrusion. The aim of the study was to evaluate blood degradation products and ferritin in the cerebrospinal fluid (CSF) of dogs with thoracolumbar IVD extrusion, and their association to clinical parameters and MRI findings. RESULTS In the CSF of dogs with IVD extrusion, both net oxyhemoglobin absorption (NOA) and net bilirubin absorption (NBA) were significantly higher compared to the control groups of dogs with steroid responsive meningitis arteritis (SRMA) and idiopathic epilepsy (IE) (P < 0.001), but NOA compared to the idiopathic epilepsy group contaminated artificially with blood (IEc) was not (P = 0.890). Ferritin concentration was significantly higher in dogs with IVD extrusion compared to dogs with IE (P = 0.034), but not to dogs with SRMA (P = 0.526). There was no association between NOA, NBA or ferritin concentration and severity or duration of clinical signs. In dogs with a higher ferritin concentration the outcome was better (P = 0.018). In dogs with evidence of hemorrhage on MRI, NOA and NBA were significantly higher (P = 0.016, P = 0.009), but not ferritin (P = 0.0628). CONCLUSION AND CLINICAL IMPORTANCE Quantification of blood degradation products and ferritin in the CSF of dogs to assess subarachnoidal hemorrhage is feasible; however, larger case numbers are needed to evaluate the relevance of NBA and ferritin as prognostic indicators.

Item Type:

Journal Article (Original Article)

Division/Institute:

05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Clinical Radiology
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Institute of Clinical Chemistry

UniBE Contributor:

Schild, Christof; Marti, Eliane Isabelle; Mirkovitch, Jelena and Schweizer, Daniela Esther

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1746-6148

Publisher:

BioMed Central

Language:

English

Submitter:

Alexandra Müller

Date Deposited:

03 Jan 2020 10:21

Last Modified:

05 Jan 2020 02:44

Publisher DOI:

10.1186/s12917-019-1878-9

PubMed ID:

31088486

Uncontrolled Keywords:

Bilirubin Oxyhemoglobin Spinal cord injury Subarachnoidal hemorrhage

BORIS DOI:

10.7892/boris.136907

URI:

https://boris.unibe.ch/id/eprint/136907

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