Translational neuroprotection research in glaucoma: a review of definitions and principles

Casson, Robert J; Chidlow, Glyn; Ebneter, Andreas; Wood, John P M; Crowston, Jonathan; Goldberg, Ivan (2012). Translational neuroprotection research in glaucoma: a review of definitions and principles. Clinical & experimental ophthalmology, 40(4), pp. 350-7. Richmond (Aus.): Wiley 10.1111/j.1442-9071.2011.02563.x

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The maintenance of vision, through prevention and attenuation of neuronal injury in glaucoma, forms the basis of current clinical practice. Currently, the reduction of intraocular pressure is the only proven method to achieve these goals. Although this strategy enjoys considerable success, some patients progress to blindness; hence, additional management options are highly desirable. Several terms describing treatment modalities of neuronal diseases with potential applicability to glaucoma are used in the literature, including neuroprotection, neurorecovery, neurorescue and neuroregeneration. These phenomena have not been defined within a coherent framework. Here, we suggest a set of definitions, postulates and principles to form a foundation for the successful translation of novel glaucoma therapies from the laboratory to the clinic.

Item Type:

Journal Article (Further Contribution)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Ebneter, Andreas

ISSN:

1442-6404

Publisher:

Wiley

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

17 Mar 2015 21:23

Publisher DOI:

10.1111/j.1442-9071.2011.02563.x

PubMed ID:

22697056

Web of Science ID:

000305283600024

URI:

https://boris.unibe.ch/id/eprint/13691 (FactScience: 220288)

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