The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020.

Simon, Hans-Uwe; Yousefi, Shida; Germic, Nina; Arnold, Isabelle C.; Haczku, Angela; Karaulov, Alexander V.; Simon, Dagmar; Rosenberg, Helene F. (2020). The Cellular Functions of Eosinophils: Collegium Internationale Allergologicum (CIA) Update 2020. International archives of allergy and immunology, 181(1), pp. 11-23. Karger 10.1159/000504847

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Eosinophils and their secretory mediators play an important role in the pathogenesis of infectious and inflammatory disorders. Although eosinophils are largely evolutionally conserved, their physiologic functions are not well understood. Given the availability of new eosinophil-targeted depletion therapies, there has been a renewed interest in understanding eosinophil biology as these strategies may result in secondary disorders when applied over long periods of time. Recent data suggest that eosinophils are not only involved in immunological effector functions but also carry out tissue protective and immunoregulatory functions that actively contribute to the maintenance of homeostasis. Prolonged eosinophil depletion may therefore result in the development of secondary disorders. Here, we review recent literature pointing to important roles for eosinophils in promoting immune defense, antibody production, activation of adipose tissue, and tissue remodeling and fibrosis. We also reflect on patient data from clinical trials that feature anti-eosinophil therapeutics.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Pharmacology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Simon, Hans-Uwe; Yousefi, Shida; Germic, Nina and Simon, Dagmar

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1018-2438

Publisher:

Karger

Language:

English

Submitter:

Sabrina Cookman

Date Deposited:

28 Jan 2020 10:35

Last Modified:

28 Jan 2020 10:45

Publisher DOI:

10.1159/000504847

PubMed ID:

31786573

Uncontrolled Keywords:

Asthma Eosinophil cytolysis Eosinophil degranulation Eosinophil extracellular traps Eosinophils Hypereosinophilic syndromes Inflammation Interleukin-5 M2 macrophages Major basic protein Mast cells Targeted therapy

BORIS DOI:

10.7892/boris.136954

URI:

https://boris.unibe.ch/id/eprint/136954

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