Metabolic correlates of dopaminergic loss in dementia with lewy bodies.

Huber, Maria; Beyer, Leonie; Prix, Catharina; Schönecker, Sonja; Palleis, Carla; Rauchmann, Boris-Stephan; Morbelli, Silvia; Chincarini, Andrea; Bruffaerts, Rose; Vandenberghe, Rik; Van Laere, Koen; Kramberger, Milica G; Trost, Maja; Grmek, Marko; Garibotto, Valentina; Nicastro, Nicolas; Frisoni, Giovanni B; Lemstra, Afina W; van der Zande, Jessica; Pilotto, Andrea; ... (2020). Metabolic correlates of dopaminergic loss in dementia with lewy bodies. Movement disorders, 35(4), pp. 595-605. Wiley-Blackwell 10.1002/mds.27945

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BACKGROUND Striatal dopamine deficiency and metabolic changes are well-known phenomena in dementia with Lewy bodies and can be quantified in vivo by 123 I-Ioflupane brain single-photon emission computed tomography of dopamine transporter and 18 F-fluorodesoxyglucose PET. However, the linkage between both biomarkers is ill-understood. OBJECTIVE We used the hitherto largest study cohort of combined imaging from the European consortium to elucidate the role of both biomarkers in the pathophysiological course of dementia with Lewy bodies. METHODS We compared striatal dopamine deficiency and glucose metabolism of 84 dementia with Lewy body patients and comparable healthy controls. After normalization of data, we tested their correlation by region-of-interest-based and voxel-based methods, controlled for study center, age, sex, education, and current cognitive impairment. Metabolic connectivity was analyzed by inter-region coefficients stratified by dopamine deficiency and compared to healthy controls. RESULTS There was an inverse relationship between striatal dopamine availability and relative glucose hypermetabolism, pronounced in the basal ganglia and in limbic regions. With increasing dopamine deficiency, metabolic connectivity showed strong deteriorations in distinct brain regions implicated in disease symptoms, with greatest disruptions in the basal ganglia and limbic system, coincident with the pattern of relative hypermetabolism. CONCLUSIONS Relative glucose hypermetabolism and disturbed metabolic connectivity of limbic and basal ganglia circuits are metabolic correlates of dopamine deficiency in dementia with Lewy bodies. Identification of specific metabolic network alterations in patients with early dopamine deficiency may serve as an additional supporting biomarker for timely diagnosis of dementia with Lewy bodies. © 2019 The Authors. Movement Disorders published by Wiley Periodicals, Inc. on behalf of International Parkinson and Movement Disorder Society.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Cumming, Paul and Rominger, Axel Oliver


600 Technology > 610 Medicine & health








Sabine Lanz

Date Deposited:

18 Dec 2019 09:17

Last Modified:

19 Apr 2020 01:31

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Lewy body dementia PET imaging dopamine deficiency glucose metabolism metabolic connectivity




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