β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice

Ruutu, Merja; Thomas, Gethin; Steck, Roland; Degli-Esposti, Mariapia A; Zinkernagel, Martin S; Alexander, Kylie; Velasco, Jared; Strutton, Geoffrey; Tran, Ai; Benham, Helen; Rehaume, Linda; Wilson, Robert J; Kikly, Kristine; Davies, Julian; Pettit, Allison R; Brown, Matthew A; McGuckin, Michael A; Thomas, Ranjeny (2012). β-glucan triggers spondylarthritis and Crohn's disease-like ileitis in SKG mice. Arthritis & rheumatism, 64(7), pp. 2211-22. Hoboken, N.J.: Wiley-Blackwell 10.1002/art.34423

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The spondylarthritides (SpA), including ankylosing spondylitis (AS), psoriatic arthritis (PsA), reactive arthritis, and arthritis associated with inflammatory bowel disease, cause chronic inflammation of the large peripheral and axial joints, eyes, skin, ileum, and colon. Genetic studies reveal common candidate genes for AS, PsA, and Crohn's disease, including IL23R, IL12B, STAT3, and CARD9, all of which are associated with interleukin-23 (IL-23) signaling downstream of the dectin 1 β-glucan receptor. In autoimmune-prone SKG mice with mutated ZAP-70, which attenuates T cell receptor signaling and increases the autoreactivity of T cells in the peripheral repertoire, IL-17-dependent inflammatory arthritis developed after dectin 1-mediated fungal infection. This study was undertaken to determine whether SKG mice injected with 1,3-β-glucan (curdlan) develop evidence of SpA, and the relationship of innate and adaptive autoimmunity to this process.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Ophthalmology

UniBE Contributor:

Zinkernagel, Martin

ISSN:

0004-3591

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:34

Last Modified:

17 Mar 2015 21:23

Publisher DOI:

10.1002/art.34423

PubMed ID:

22328069

Web of Science ID:

000305742800017

URI:

https://boris.unibe.ch/id/eprint/13703 (FactScience: 220301)

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