Directional Local Field Potentials in the Subthalamic Nucleus during Deep Brain Implantation of Parkinson’s Disease Patients

Nguyen, Thuy Anh Khoa; Schüpbach, Michael; Mercanzini, André; Drainsart, Alain; Pollo, Claudio (2020). Directional Local Field Potentials in the Subthalamic Nucleus during Deep Brain Implantation of Parkinson’s Disease Patients [Dataset]. In: Frontiers in Human Neuroscience. Frontiers

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Segmented deep brain stimulation leads feature directional electrodes, that allow for a finer spatial control of electrical stimulation compared to traditional ring-shaped electrodes. These segmented leads have demonstrated enlarged therapeutic windows and have thus the potential to improve the treatment of Parkinson’s disease patients. However, this is accompanied by complex and time-consuming device programming. Here, we investigated whether directional local field potentials can help identify the best stimulation direction to assist device programming. Four Parkinson’s disease patients underwent routine implantation of the subthalamic nucleus. First, local field potentials were recorded in three directions for two conditions: In one condition the patient was at rest, in the other condition the patient moved their arm. Second, current thresholds for therapeutic and side effects were identified intraoperatively for directional stimulation. This determined the 1st, 2nd and 3rd best stimulation direction. The spectral power of the beta frequency band (13–35 Hz) and its sub-bands were analyzed in more detail post-hoc. The direction with the highest spectral power in the total beta band was most indicative of the 1st best stimulation direction. The resting condition seemed to be slightly more informative about the best stimulation direction than the moving condition. Directional local field potentials can therefore help identify the best stimulation direction. Further studies with larger sample sizes are needed to better distinguish the informative value of different conditions and the beta sub-bands.

Item Type:

Dataset

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Nguyen, Thuy Anh Khoa; Schüpbach, Michael and Pollo, Claudio

Subjects:

600 Technology > 610 Medicine & health

Publisher:

Frontiers

Funders:

Organisations 10271 not found.

Language:

English

Submitter:

Thuy Anh Khoa Nguyen

Date Deposited:

03 Feb 2020 10:20

Last Modified:

28 Feb 2020 12:01

Uncontrolled Keywords:

Deep brain stimulation; local field potentials; Parkinson's disease

BORIS DOI:

10.7892/boris.137062

URI:

https://boris.unibe.ch/id/eprint/137062

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