Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

Guarino, Maria; Dufour, Jean-François (2019). Nicotinamide and NAFLD: Is There Nothing New Under the Sun? Metabolites, 9(9) MDPI 10.3390/metabo9090180

Preview

Text metabolites-09-00180.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (674kB) | Preview

Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD's therapeutic role for pellagra. This review addresses some of the recent findings on NAD physiopathology and their effects on nonalcoholic fatty liver disease (NAFLD) pathogenesis, which need to be considered in the search for a better therapeutic approach. Reduced NAD concentrations contribute to the dysmetabolic imbalance and consequently to the pathogenesis of NAFLD. In this perspective, the dietary supplementation or the pharmacological modulation of NAD levels appear to be an attractive strategy. These reviewed studies open the doors to growing interest in NAD metabolism for NAFLD diagnosis, prevention, and treatment. Future rigorous clinical studies in humans will be necessary to validate these preliminary but promising results.

Interest & Impact

Downloads

111 since deposited on 14 Jan 2020
18 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item