Nicotinamide and NAFLD: Is There Nothing New Under the Sun?

Guarino, Maria; Dufour, Jean-François (2019). Nicotinamide and NAFLD: Is There Nothing New Under the Sun? Metabolites, 9(9) MDPI 10.3390/metabo9090180

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Nicotinamide adenine dinucleotide (NAD) has a critical role in cellular metabolism and energy homeostasis. Its importance has been established early with the discovery of NAD's therapeutic role for pellagra. This review addresses some of the recent findings on NAD physiopathology and their effects on nonalcoholic fatty liver disease (NAFLD) pathogenesis, which need to be considered in the search for a better therapeutic approach. Reduced NAD concentrations contribute to the dysmetabolic imbalance and consequently to the pathogenesis of NAFLD. In this perspective, the dietary supplementation or the pharmacological modulation of NAD levels appear to be an attractive strategy. These reviewed studies open the doors to growing interest in NAD metabolism for NAFLD diagnosis, prevention, and treatment. Future rigorous clinical studies in humans will be necessary to validate these preliminary but promising results.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology

UniBE Contributor:

Guarino, Maria and Dufour, Jean-François

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2218-1989

Publisher:

MDPI

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

14 Jan 2020 08:28

Last Modified:

14 Jan 2020 08:28

Publisher DOI:

10.3390/metabo9090180

PubMed ID:

31510030

Uncontrolled Keywords:

NAFLD nicotinamide steatosis

BORIS DOI:

10.7892/boris.137071

URI:

https://boris.unibe.ch/id/eprint/137071

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