The Pulse-Respiration Quotient: A Powerful but Untapped Parameter for Modern Studies About Human Physiology and Pathophysiology.

Scholkmann, Felix; Wolf, Ursula (2019). The Pulse-Respiration Quotient: A Powerful but Untapped Parameter for Modern Studies About Human Physiology and Pathophysiology. Frontiers in physiology, 10, p. 371. Frontiers Research Foundation 10.3389/fphys.2019.00371

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A specific and unique aspect of cardiorespiratory activity can be captured by dividing the heart rate (HR) by the respiration rate (RR), giving the pulse-respiration quotient (PRQ = HR/RR). In this review article, we summarize the main findings of studies using and investigating the PRQ. We describe why the PRQ is a powerful parameter that captures complex regulatory states of the cardiorespiratory system, and we highlight the need to re-introduce the use of this parameter into modern studies about human physiology and pathophysiology. In particular, we show that the PRQ (i) changes during human development, (ii) is time-dependent (ultradian, circadian, and infradian rhythms), (iii) shows specific patterns during sleep, (iv) changes with physical activity and body posture, (v) is linked with psychophysical and cognitive activity, (vi) is sex-dependent, and (vii) is determined by the individual physiological constitution. Furthermore, we discuss the medical aspects of the PRQ in terms of applications for disease classification and monitoring. Finally, we explain why there should be a revival in the use of the PRQ for basic research about human physiology and for applications in medicine, and we give recommendations for the use of the PRQ in studies and medical applications.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Medical Education > Institute of Complementary and Integrative Medicine (IKIM)

UniBE Contributor:

Scholkmann, Felix and Wolf, Ursula

Subjects:

600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 310 Statistics
500 Science > 570 Life sciences; biology

ISSN:

1664-042X

Publisher:

Frontiers Research Foundation

Language:

English

Submitter:

Hamoon Zohdi

Date Deposited:

13 Jan 2020 11:52

Last Modified:

19 Jan 2020 02:48

Publisher DOI:

10.3389/fphys.2019.00371

PubMed ID:

31024336

Uncontrolled Keywords:

PRQ cardio-respiratory coupling chronobiology integrative human physiology pulse-respiration quotient

BORIS DOI:

10.7892/boris.137095

URI:

https://boris.unibe.ch/id/eprint/137095

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