Effect of dental caries on periodontal inflammatory status: A split-mouth study.

Taso, Ervin; Stefanovic, Vladimir; Gaudin, Alexis; Grujic, Jovan; Maldonado, Estela; Petkovic-Curcin, Aleksandra; Vojvodic, Danilo; Sculean, Anton; Rakic, Mia (2020). Effect of dental caries on periodontal inflammatory status: A split-mouth study. Archives of oral biology, 110, p. 104620. Elsevier Science 10.1016/j.archoralbio.2019.104620

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OBJECTIVE

This controlled split-mouth study aimed to estimate the effect of caries and related treatment on concentrations of interleukin (IL)-2, interferon (IFN)-γ, IL-12, IL-17A, IL-13, IL-10, IL-6, IL-5, IL-4, IL-22, tumor necrosis factor (TNF)-α, and IL1-β in gingival crevicular fluid (GCF) of caries affected teeth before (B), 7 (7D) and 30 (30D) days post-treatment and to compare them with concentrations from healthy teeth.

DESIGN

Study population included 81 systemically and periodontally healthy non-smokers exhibiting at least one shallow occlusal/ inter-proximal caries and one healthy tooth from the same morphologic group at the contralateral position. Following clinical exam, the GCF samples were collected baseline as well as 7D and 30D, while the biomarker measurement was performed using multiplex flowcytometry.

RESULTS

Caries affected teeth exhibited significantly higher levels of IFN-γ, IL-1β, IL-2, IL-4 and IL-6 when compared to healthy teeth. Post-treatment cytokines levels showed general trend of increase when compared to baseline, that was significant for IL-22 and IL-17 at 7D, while IFN-γ was significantly increased at 7D compared to the healthy teeth. At 30D, IFN-γ, TNF-α, IL-17 and IL-4 levels were significantly increased when compared to healthy teeth, while IL-2 levels were significantly higher than baseline levels.

CONCLUSION

Considering significantly increased periodontal levels of inflammatory markers in caries affected teeth and in response to performed treatment, it seems that dental caries and related restorative treatment might contribute to periodontal inflammation via additive effects already in early-stage caries.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology

UniBE Contributor:

Sculean, Anton

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0003-9969

Publisher:

Elsevier Science

Language:

English

Submitter:

Doris Burri

Date Deposited:

14 Jan 2020 15:11

Last Modified:

19 Jan 2020 02:48

Publisher DOI:

10.1016/j.archoralbio.2019.104620

PubMed ID:

31791000

Uncontrolled Keywords:

Biomarker Caries Cytokine Gingival crevicular fluid Inflammation Periodontitis

BORIS DOI:

10.7892/boris.137263

URI:

https://boris.unibe.ch/id/eprint/137263

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