Schawkat, Khoschy; Sah, Bert-Ram; Ter Voert, Edwin E; Delso, Gaspar; Wurnig, Moritz; Becker, Anton S; Leibl, Sebastian; Schneider, Paul M; Reiner, Cäcilia S; Huellner, Martin W; Veit-Haibach, Patrick (2021). Role of intravoxel incoherent motion parameters in gastro-esophageal cancer: relationship with 18F-FDG-PET, CT perfusion and MR perfusion imaging parameters. The quarterly journal of nuclear medicine and molecular imaging, 65(2), pp. 178-186. Edizioni Minerva Medica 10.23736/S1824-4785.19.03153-4
Full text not available from this repository. (Request a copy)BACKGROUND
Identification of pre-therapeutic predictive markers in gastro-esophageal cancer is essential for individual-oriented treatment. This study evaluated the relationship of multimodality parameters derived from intravoxel incoherent motion method (IVIM), 18F- FDG-PET, CT perfusion and dynamic contrast enhanced MRI in patients with gastro- esophageal cancer and investigated their histopathological correlation.
METHODS
Thirty-one consecutive patients (28 male; median age 63.9 years; range 37-84 years) with gastro-esophageal adenocarcinoma (n=22) and esophageal squamous cell carcinoma (n=9) were analyzed. IVIM parameters: pseudodiffusion (D*), perfusion fraction (fp), true diffusion (D) and the threshold b-value (bval); PET-parameters: SUVmax, metabolic tumor volume (MTV) and total lesion glycolysis (TLG); CT perfusion parameters: blood flow (BF), blood volume (BV) and mean transit time (MTT); and MR perfusion parameters: time to enhance, positive enhancement integral, time-to-peak (TTP), maximum- slope-of-increase, and maximum-slope-of-decrease were determined, and correlated to each other and to histopathology.
RESULTS
IVIM and PET parameters showed significant negative correlations: MTV & bval (rs = -0.643, p = 0.002), TLG & bval (rs = -0.699, p < 0.01) and TLG & fp (rs = -0.577, p = 0.006). Positive correlation was found for TLG & D (rs = 0.705, p = 0.000). Negative correlation was found for bval & staging (rs = 0.590, p = 0.005). Positive correlation was found for positive enhancement interval & BV (rs = 0.547, p = 0.007), BF & regression index (rs = 0.753, p = 0.005) and for time-to-peak & staging (rs = 0.557, p = 0.005).
CONCLUSIONS
IVIM parameters (bval, fp, D) provide quantitative information and correlate with PET parameters (MTV, TLG) and staging. IVIM might be a useful tool for additional characterization of gastro-esophageal cancer.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Institute of Diagnostic, Interventional and Paediatric Radiology |
UniBE Contributor: |
Sah, Bert-Ram |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1827-1936 |
Publisher: |
Edizioni Minerva Medica |
Language: |
English |
Submitter: |
Maria de Fatima Henriques Bernardo |
Date Deposited: |
14 Jan 2020 14:56 |
Last Modified: |
05 Dec 2022 15:34 |
Publisher DOI: |
10.23736/S1824-4785.19.03153-4 |
PubMed ID: |
31496202 |
URI: |
https://boris.unibe.ch/id/eprint/137266 |
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