Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents.

Terziroli Beretta-Piccoli, Benedetta; Di Bartolomeo, Claudia; Deleonardi, Gaia; Grondona, Ana Gabriela; Silvestri, Tania; Tesei, Cinzia; Melidona, Laura; Cerny, Andreas; Mertens, Joachim; Semmo, Nasser; Semela, David; Moradpour, Darius; Mieli-Vergani, Giorgina; Vergani, Diego; Muratori, Luigi (2019). Autoimmune liver serology before and after successful treatment of chronic hepatitis C by direct acting antiviral agents. Journal of autoimmunity, 102, pp. 89-95. Elsevier 10.1016/j.jaut.2019.04.019

[img] Text
1-s2.0-S0896841119301866-main.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (680kB) | Request a copy

BACKGROUND AND AIMS

Chronic hepatitis C virus (HCV) infection is associated with a wide range of immunopathological manifestations, which are significantly improved by successful interferon-based treatment. There is paucity of data on the impact of interferon-free HCV clearance on immunopathological manifestations, which might be expected to disappear more frequently as compared to what reported in interferon-induced HCV-clearance. We have investigated liver autoimmune serology before and after interferon-free clearance of HCV by treatment with direct acting antiviral agents (DAA).

METHOD

Patients within the Swiss Hepatitis C Cohort Study who underwent successful (SVR 12) HCV treatment with DAA were tested for autoimmune liver serology according to dedicated guidelines before and at least 6 months after end of treatment.

RESULTS

A total of 235 patients were included; 62% males; median age 56 years; 27% with cirrhosis. Median time between end of DAA treatment and post-treatment serum sampling was 17 months. At least one autoantibody before treatment was found in 175 (74%) patients ; 32 (14%) were positive for 2 autoantibodies; no patient was positive for anti-SLA, anti-LC1 or typical AMA before or after DAA. ANA disappeared in 34%, SMA in 52% and anti-LKM1 in one of two patients after successful treatment, but, unexpectedly, one or more autoantibodies appeared in 27% of pre-treatment negative subjects.

CONCLUSION

HCV clearance by DAA is associated with autoantibody disappearance in more than one third of the patients who were positive before treatment. However, the majority of the patients remain autoantibody-positive and 27% of those who were negative before treatment developed autoantibodies after DAA-induced HCV clearance. These data confirm that HCV infection is associated with autoimmunity and show that the autoimmune imprint persists after viral clearance by DAA, suggesting that long-term follow-up may be warranted.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Semmo, Nasser

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0896-8411

Publisher:

Elsevier

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

17 Jan 2020 14:31

Last Modified:

17 Jan 2020 14:31

Publisher DOI:

10.1016/j.jaut.2019.04.019

PubMed ID:

31047768

BORIS DOI:

10.7892/boris.137299

URI:

https://boris.unibe.ch/id/eprint/137299

Actions (login required)

Edit item Edit item
Provide Feedback