Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis.

Hooijmans, Carlijn R; Hlavica, Martin; Schuler, Florian; Good, Nicolas; Good, Andrin; Baumgartner, Lisa; Galeno, Gianluca; Schneider, Marc P; Jung, Tarzis; de Vries, Rob; Ineichen, Benjamin V (2019). Remyelination promoting therapies in multiple sclerosis animal models: a systematic review and meta-analysis. Scientific reports, 9(1), p. 822. Springer Nature 10.1038/s41598-018-35734-4

[img]
Preview
Text
Hooijmans, 2019, Remyelination promoting therapies.pdf - Published Version
Available under License Creative Commons: Attribution (CC-BY).

Download (3MB) | Preview

An unmet but urgent medical need is the development of myelin repair promoting therapies for Multiple Sclerosis (MS). Many such therapies have been pre-clinically tested using different models of toxic demyelination such as cuprizone, ethidium bromide, or lysolecithin and some of the therapies already entered clinical trials. However, keeping track on all these possible new therapies and their efficacy has become difficult with the increasing number of studies. In this study, we aimed at summarizing the current evidence on such therapies through a systematic review and at providing an estimate of the effects of tested interventions by a meta-analysis. We show that 88 different therapies have been pre-clinically tested for remyelination. 25 of them (28%) entered clinical trials. Our meta-analysis also identifies 16 promising therapies which did not enter a clinical trial for MS so far, among them Pigment epithelium-derived factor, Plateled derived growth factor, and Tocopherol derivate TFA-12.We also show that failure in bench to bedside translation from certain therapies may in part be attributable to poor study quality. By addressing these problems, clinical translation might be smoother and possibly animal numbers could be reduced.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology

UniBE Contributor:

Schuler, Florian

Subjects:

600 Technology > 610 Medicine & health

ISSN:

2045-2322

Publisher:

Springer Nature

Language:

English

Submitter:

Chantal Kottler

Date Deposited:

13 Jan 2020 13:50

Last Modified:

13 Mar 2021 16:57

Publisher DOI:

10.1038/s41598-018-35734-4

PubMed ID:

30696832

BORIS DOI:

10.7892/boris.137321

URI:

https://boris.unibe.ch/id/eprint/137321

Actions (login required)

Edit item Edit item
Provide Feedback