Use of Steatotic Grafts in Liver Transplantation: Current Status.

Álvarez-Mercado, Ana I; Gulfo, José; Romero Gómez, Manuel; Jiménez-Castro, Mónica B; Gracia-Sancho, Jordi; Peralta, Carmen (2019). Use of Steatotic Grafts in Liver Transplantation: Current Status. Liver transplantation, 25(5), pp. 771-786. Wiley 10.1002/lt.25430

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In the field of liver transplantation, the demand for adequate allografts greatly exceeds the supply. Therefore, expanding the donor pool to match the growing demand is mandatory. The present review summarizes current knowledge of the pathophysiology of ischemia/reperfusion injury in steatotic grafts, together with recent pharmacological approaches aimed at maximizing the utilization of these livers for transplantation. We also describe the preclinical models currently available to understand the molecular mechanisms controlling graft viability in this specific type of donor, critically discussing the heterogeneity in animal models, surgical methodology, and therapeutic interventions. This lack of common approaches and interventions makes it difficult to establish the pathways involved and the relevance of isolated discoveries, as well as their transferability to clinical practice. Finally, we discuss how new therapeutic strategies developed from experimental studies are promising but that further studies are warranted to translate them to the bedside.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie

UniBE Contributor:

Gracia Sancho, Jorge Sergio

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1527-6465

Publisher:

Wiley

Language:

English

Submitter:

Thi Thao Anh Pham

Date Deposited:

20 Jan 2020 13:46

Last Modified:

05 Dec 2022 15:34

Publisher DOI:

10.1002/lt.25430

PubMed ID:

30740859

BORIS DOI:

10.7892/boris.137327

URI:

https://boris.unibe.ch/id/eprint/137327

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