Digital versus analogue PET in [68Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison.

Alberts, Ian; Prenosil, George; Sachpekidis, Christos; Weitzel, Thilo; Shi, Kuangyu; Rominger, Axel; Afshar-Oromieh, Ali (2020). Digital versus analogue PET in [68Ga]Ga-PSMA-11 PET/CT for recurrent prostate cancer: a matched-pair comparison. European journal of nuclear medicine and molecular imaging, 47(3), pp. 614-623. Springer-Verlag 10.1007/s00259-019-04630-y

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Digital PET/CT scanners represent a significant step forward in molecular imaging. We report here the clinical impact of digital PET in PSMA-PET/CT.


In this retrospective study, 88 consecutive patients who underwent [68Ga]Ga-PSMA-11 PET/CT on a digital PET/CT (dPET/CT) scanner for recurrent prostate cancer (PC) were included in a first cohort. In a second step, 88 individuals who underwent an analogue [68Ga]Ga-PSMA-11 PET/CT (aPET/CT) were selected after they were matched to the first cohort for clinical parameters. Following consensus read by two nuclear medicine physicians, the number and type of PC lesions as well as benign, PSMA-positive lesions were recorded. The results were complemented by extensive [68Ga]Ga phantom measurements to determine imaging characteristics of both scanners.


dPET/CT revealed a greater number of PC lesions compared to aPET/CT (326 versus 142) as well as a proportional increase in benign causes of tracer-uptake (144 versus 65). A greater number of scans were noted as pathological for PC on dPET/CT (74/88) compared to aPET/CT (64/88, p < 0.05). The PSMA positivity rate for PC was significantly higher in dPET/CT for the lowest PSA values (PSA < 2.0 ng/ml, p < 0.05).


dPET/CT detected more PC lesions compared to aPET/CT. A significantly higher rate of pathological PET/CTs was noted in the group with the lowest PSA values. A higher number of benign PSMA-positive lesions were also noted in dPET/CT. The differences could be plausibly explained by the measured imaging characteristics of the scanners.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Radiology, Neuroradiology and Nuclear Medicine (DRNN) > Clinic of Nuclear Medicine

UniBE Contributor:

Alberts, Ian Leigh, Prenosil, George, Sachpekidis, Christos, Weitzel, Thilo, Shi, Kuangyu, Rominger, Axel Oliver, Afshar Oromieh, Ali


600 Technology > 610 Medicine & health








Sabine Lanz

Date Deposited:

22 Jan 2020 14:43

Last Modified:

05 Dec 2022 15:34

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

Digital PET PET/CT PSMA Positron emission tomography Prostate cancer Prostate-specific membrane antigen




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