Patterns of care for ruptured aneurysms of the middle cerebral artery: analysis of a Swiss national database (Swiss SOS).

Maldaner, Nicolai; Steinsiepe, Valentin K; Goldberg, Johannes; Fung, Christian; Bervini, David; May, Adrien; Bijlenga, Philippe; Schaller, Karl; Roethlisberger, Michel; Zumofen, Daniel W; D'Alonzo, Donato; Marbacher, Serge; Fandino, Javier; Maduri, Rodolfo; Daniel, Roy Thomas; Burkhardt, Jan-Karl; Chiappini, Alessio; Robert, Thomas; Schatlo, Bawarjan; Seule, Martin A; ... (2019). Patterns of care for ruptured aneurysms of the middle cerebral artery: analysis of a Swiss national database (Swiss SOS). (In Press). Journal of neurosurgery, pp. 1-10. American Association of Neurological Surgeons 10.3171/2019.9.JNS192055

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OBJECTIVE The objective of this study was to determine patterns of care and outcomes in ruptured intracranial aneurysms (IAs) of the middle cerebral artery (MCA) in a contemporary national cohort. METHODS The authors conducted a retrospective analysis of prospective data from a nationwide multicenter registry of all aneurysmal subarachnoid hemorrhage (aSAH) cases admitted to a tertiary care neurosurgical department in Switzerland in the years 2009-2015 (Swiss Study on Aneurysmal Subarachnoid Hemorrhage [Swiss SOS]). Patterns of care and outcomes at discharge and the 1-year follow-up in MCA aneurysm (MCAA) patients were analyzed and compared with those in a control group of patients with IAs in locations other than the MCA (non-MCAA patients). Independent predictors of a favorable outcome (modified Rankin Scale score ≤ 3) were identified, and their effect size was determined. RESULTS Among 1866 consecutive aSAH patients, 413 (22.1%) harbored an MCAA. These MCAA patients presented with higher World Federation of Neurosurgical Societies grades (p = 0.007), showed a higher rate of concomitant intracerebral hemorrhage (ICH; 41.9% vs 16.7%, p < 0.001), and experienced delayed cerebral ischemia (DCI) more frequently (38.9% vs 29.4%, p = 0.001) than non-MCAA patients. After adjustment for confounders, patients with MCAA were as likely as non-MCAA patients to experience DCI (aOR 1.04, 95% CI 0.74-1.45, p = 0.830). Surgical treatment was the dominant treatment modality in MCAA patients and at a significantly higher rate than in non-MCAA patients (81.7% vs 36.7%, p < 0.001). An MCAA location was a strong independent predictor of surgical treatment (aOR 8.49, 95% CI 5.89-12.25, p < 0.001), despite statistical adjustment for variables traditionally associated with surgical treatment, such as (space-occupying) ICH (aOR 1.73, 95% CI 1.23-2.45, p = 0.002). Even though MCAA patients were less likely to die during the acute hospitalization (aOR 0.52, 0.30-0.91, p = 0.022), their rate of a favorable outcome was lower at discharge than that in non-MCAA patients (55.7% vs 63.7%, p = 0.003). At the 1-year follow-up, 68.5% and 69.6% of MCAA and non-MCAA patients, respectively, had a favorable outcome (p = 0.676). CONCLUSIONS Microsurgical occlusion remains the predominant treatment choice for about 80% of ruptured MCAAs in a European industrialized country. Although patients with MCAAs presented with worse admission grades and greater rates of concomitant ICH, in-hospital mortality was lower and long-term disability was comparable to those in patients with non-MCAA.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery

UniBE Contributor:

Goldberg, Johannes and Bervini, David

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0022-3085

Publisher:

American Association of Neurological Surgeons

Language:

English

Submitter:

Nicole Söll

Date Deposited:

24 Jan 2020 12:42

Last Modified:

24 Jan 2020 12:51

Publisher DOI:

10.3171/2019.9.JNS192055

PubMed ID:

31731273

Uncontrolled Keywords:

BRAT = Barrow Ruptured Aneurysm Trial DCI = delayed cerebral ischemia IA = intracranial aneurysm ICH = intracerebral hemorrhage ISAT = International Subarachnoid Aneurysm Trial MCA MCA = middle cerebral artery MCAA = MCA aneurysm RCT = randomized controlled trial WFNS = World Federation of Neurosurgical Societies aOR = adjusted odds ratio aSAH = aneurysmal subarachnoid hemorrhage aneurysmal subarachnoid hemorrhage mRS = modified Rankin Scale outcome pattern of care ruptured middle cerebral artery aneurysms surgical treatment vascular disorders

BORIS DOI:

10.7892/boris.137428

URI:

https://boris.unibe.ch/id/eprint/137428

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